1421703-65-2

Upstream product

• 110-89-4 piperidine 
• 1421703-93-6 4-(5,6-dichloro-4-(dimethylcarbamoyl)-2-(isopropylamino)-1H-benzo[d]imidazol-1-yl)phenyl trifluoromethanesulfonate 
• 1421703-92-5 5,6-dichloro-1-(4-hydroxyphenyl)-2-(isopropylamino)-N,N-dimethyl-1H-benzo[d]imidazole-4-carboxamide 
• 1421703-91-4 5,6-dichloro-2-(isopropylamino)-1-(4-methoxyphenyl)-N,N-dimethyl-1H-benzo[d]imidazole-4-carboxamide 
• 1421703-90-3 5,6-dichloro-2-(isopropylamino)-1-(4-methoxyphenyl)-1H-benzo[d]imidazole-4-carboxylic acid 
• 1421703-89-0 5,6-dichloro-2-(isopropylamino)-1-(4-methoxyphenyl)-1H-benzo[d]imidazole-4-carbonitrile 
• 1421703-88-9 4-bromo-5,6-dichloro-N-isopropyl-1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-amine 
• 193527-10-5 4-bromo-5,6-dichloro-N-isopropyl-1H-benzo[d]imidazol-2-amine 
• 211694-43-8 4-bromo-2,5,6-trichloro-1H-benzo[d]imidazole 
• 1421703-87-8 4-bromo-5,6-dichloro-1H-benzo[d]imidazol-2-ol 
• 172215-94-0 3-bromo-4,5-dichlorophenylene-1,2-diamine 
• 172215-93-9 2-bromo-3,4-dichloro-6-nitroaniline 
• 6641-64-1 4,5-dichloro-2-nitroaniline 

Relevant academic research and scientific papers

Optimization of a novel series of TRPV4 antagonists with in vivo activity in a model of pulmonary edema

High-throughput screening and subsequent hit optimization identified 1-piperidinylbenzimidazoles, exemplified by compound 1, as TRPV4 inhibitors. Lead optimization identified potent TRPV4 blocker 19, which has good target activity and pharmacokinetic properties. Inhibitor 19 was then profiled in an in vivo rat model, demonstrating its ability to inhibit TRPV4-mediated pulmonary edema.