1421768-11-7

Upstream product

• 920958-49-2 benzyl-(5-hydroxy-pentyl)-carbamic acid benzyl ester 
• 1421767-97-6 (2-methyl-5-tert-butylphenyl) 2,6-di-O-benzyl-3-O-(4-bromobenzyl)-4-O-levulinoyl-1-thio-β-D-glucopyranoside 
• 1421767-96-5 (2-methyl-5-tert-butylphenyl) 2,6-di-O-benzyl-3-O-(4-bromobenzyl)-1-thio-β-D-glucopyranoside 
• 1421758-31-7 (2-methyl-5-tert-butylphenyl) 1-thio-β-D-glucopyranoside 
• 1334540-33-8 (2-methyl-5-tert-butylphenyl) 2,3,4,6-tetra-O-acetyl-1-S-β-D-thioglucopyranoside 
• 604-69-3 β-D-glucose pentaacetate 

Downstream Products

• 1421768-12-8 N-(benzyl)benzyloxycarbonyl-5-aminopentanyl 2,6-di-O-benzyl-3-O-(4-bromobenzyl)-α-D-glucopyranoside 

Relevant academic research and scientific papers

OLIGOSACCHARIDES AND OLIGOSACCHARIDE-PROTEIN CONJUGATES DERIVED FROM CLOSTRIDIUM DIFFICILE POLYSACCARIDE PS-I, METHODS OF SYNTHESIS AND USES THEREOF, IN PARTICULAR AS VACCINES AND DIAGNOSTIC TOOLS

The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap- ( 1→3 ) -β-D-Glcp- ( 1→4 ) - [a-L-Rhap- ( 1→3 ] -a-D-Glcp- ( 1→2 ) -a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.