1421840-55-2Relevant academic research and scientific papers
Method for manufacturing a new dephosphorizing ligand homochiral (by machine translation)
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Paragraph 0125; 0127, (2016/10/10)
Disclosed are methods for making chiral phosphorus ligands including chiral phosphines, chiral phosphine oxides, phosphonamides, and aminophosphines. The chiral phosphorus ligands prepared by the methods of the invention are useful as components of chiral catalysts, e.g., transition metal complexes.
Efficient asymmetric synthesis of P -chiral phosphine oxides via properly designed and activated benzoxazaphosphinine-2-oxide agents
Han, Zhengxu S.,Goyal, Navneet,Herbage, Melissa A.,Sieber, Joshua D.,Qu, Bo,Xu, Yibo,Li, Zhibin,Reeves, Jonathan T.,Desrosiers, Jean-Nicolas,Ma, Shengli,Grinberg, Nelu,Lee, Heewon,Mangunuru, Hari P. R.,Zhang, Yongda,Krishnamurthy, Dhileep,Lu, Bruce Z.,Song, Jinhua J.,Wang, Guijun,Senanayake, Chris H.
, p. 2474 - 2477 (2013/03/28)
A general, efficient, and highly diastereoselective method for the synthesis of structurally and sterically diverse P-chiral phosphine oxides was developed. The method relies on sequential nucleophilic substitution on the versatile chiral phosphinyl transfer agent 1,3,2-benzoxazaphosphinine-2-oxide, which features enhanced and differentiated P-N and P-O bond reactivity toward nucleophiles. The reactivities of both bonds are fine-tuned to allow cleavage to occur even with sterically hindered nucleophiles under mild conditions.
