1421840-56-3Relevant academic research and scientific papers
Method for manufacturing a new dephosphorizing ligand homochiral (by machine translation)
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Paragraph 0061; 0062; 0067; 0068, (2016/10/10)
Disclosed are methods for making chiral phosphorus ligands including chiral phosphines, chiral phosphine oxides, phosphonamides, and aminophosphines. The chiral phosphorus ligands prepared by the methods of the invention are useful as components of chiral catalysts, e.g., transition metal complexes.
Efficient asymmetric synthesis of structurally diverse p-stereogenic phosphinamides for catalyst design
Han, Zhengxu S.,Zhang, Li,Xu, Yibo,Sieber, Joshua D.,Marsini, Maurice A.,Li, Zhibin,Reeves, Jonathan T.,Fandrick, Keith R.,Patel, Nitinchandra D.,Desrosiers, Jean-Nicolas,Qu, Bo,Chen, Anji,Rudzinski, Diandra M.,Samankumara, Lalith P.,Ma, Shengli,Grinberg, Nelu,Roschangar, Frank,Yee, Nathan K.,Wang, Guijun,Song, Jinhua J.,Senanayake, Chris H.
, p. 5474 - 5477 (2015/04/27)
The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a general, efficient, and highly enantioselective method for the synthesis of structurally diverse P-stereogenic phosphinamides. The method relies on nucleophilic substitution of a chiral phosphinate derived from the versatile chiral phosphinyl transfer agent 1,3,2-benzoxazaphosphinine-2-oxide. These chiral phosphinamides were utilized for the first synthesis of readily tunable P-stereogenic Lewis base organocatalysts, which were used successfully for highly enantioselective catalysis.
Efficient asymmetric synthesis of P -chiral phosphine oxides via properly designed and activated benzoxazaphosphinine-2-oxide agents
Han, Zhengxu S.,Goyal, Navneet,Herbage, Melissa A.,Sieber, Joshua D.,Qu, Bo,Xu, Yibo,Li, Zhibin,Reeves, Jonathan T.,Desrosiers, Jean-Nicolas,Ma, Shengli,Grinberg, Nelu,Lee, Heewon,Mangunuru, Hari P. R.,Zhang, Yongda,Krishnamurthy, Dhileep,Lu, Bruce Z.,Song, Jinhua J.,Wang, Guijun,Senanayake, Chris H.
, p. 2474 - 2477 (2013/03/28)
A general, efficient, and highly diastereoselective method for the synthesis of structurally and sterically diverse P-chiral phosphine oxides was developed. The method relies on sequential nucleophilic substitution on the versatile chiral phosphinyl transfer agent 1,3,2-benzoxazaphosphinine-2-oxide, which features enhanced and differentiated P-N and P-O bond reactivity toward nucleophiles. The reactivities of both bonds are fine-tuned to allow cleavage to occur even with sterically hindered nucleophiles under mild conditions.
