1421859-13-3Relevant academic research and scientific papers
Palladium-catalyzed picolinamide-directed alkylation of unactivated C(sp3)-H bonds with alkyl iodides
Zhang, Shu-Yu,He, Gang,Nack, William A.,Zhao, Yingsheng,Li, Qiong,Chen, Gong
, p. 2124 - 2127 (2013)
We report an efficient method for the alkylation of γ-C(sp 3)-H bonds of picolinamide-protected aliphatic amine substrates with primary alkyl iodides via palladium catalysis. Ag2CO3 and dibenzyl phosphate, (BnO)2PO2H, are critical promoters of this reaction. These reactions provide a convenient and straightforward method for the preparation of high-value N-containing products from readily available amine and alkyl iodide precursors.
