142186-04-7

Upstream product

• 89615-28-1 (6aR,6bR,12bR,12cR)-6a,6b,12b,12c-Tetrahydro-5,8-dioxa-dibenzo[a,i]biphenylene-6,7-dione 
• 64-17-5 ethanol 
• 91-64-5 coumarin 

Downstream Products

• 18221-50-6 dihydroxy-stilbene 
• 623-91-6 diethyl Fumarate 
• 527751-03-7 (1R,2R,3R,4R)-3,4-Bis-{2-[bis-(4-tert-butyl-phenyl)-phosphinoyl]-phenyl}-cyclobutane-1,2-dicarboxylic acid diethyl ester 
• 527750-99-8 (1R,2R,3R,4R)-3,4-Bis-{2-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-phenyl}-cyclobutane-1,2-dicarboxylic acid diethyl ester 
• 527751-02-6 (1R,2R,3R,4R)-3,4-Bis-{2-[bis-(4-methoxy-phenyl)-phosphinoyl]-phenyl}-cyclobutane-1,2-dicarboxylic acid diethyl ester 
• 527751-01-5 (1R,2R,3R,4R)-3,4-Bis-[2-(di-m-tolyl-phosphinoyl)-phenyl]-cyclobutane-1,2-dicarboxylic acid diethyl ester 
• 527751-00-4 (1R,2R,3R,4R)-3,4-Bis-[2-(di-p-tolyl-phosphinoyl)-phenyl]-cyclobutane-1,2-dicarboxylic acid diethyl ester 
• 527750-98-7 (1R,2R,3R,4R)-3,4-Bis-[2-(diphenyl-phosphinoyl)-phenyl]-cyclobutane-1,2-dicarboxylic acid diethyl ester 
• 527750-97-6 (1R,2R,3R,4R)-3,4-Bis-(2-trifluoromethanesulfonyloxy-phenyl)-cyclobutane-1,2-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

A new type of C2-symmetric bisphospine ligands with a cyclobutane backbone: Practical synthesis and application

(Matrix presented) A highly efficient and practical optical resolution of anti-head-to-head racemic coumarin dimer, (±)-5, by molecular complexation with TADDOL (6) through hydrogen bonding and a convenient transformation of enantiopure 5 to a new type of C2-symmetric bisphosphine ligand (3) have been achieved. The asymmetric induction efficiency of these chiral bisphosphine ligands was evaluated in Pd-catalyzed asymmetric allylic substitution, affording the allylic substitution products in excellent yield (up to 99%) and enantioselectivity (up to 98.9% ee).