527751-01-5

Upstream product

• 145290-34-2 bis(3-methylphenyl)phosphine oxide 
• 527750-97-6 (1R,2R,3R,4R)-3,4-Bis-(2-trifluoromethanesulfonyloxy-phenyl)-cyclobutane-1,2-dicarboxylic acid diethyl ester 
• 91-64-5 coumarin 
• 142186-04-7 (1R,2R,3R,4R)-3,4-Bis-(2-hydroxy-phenyl)-cyclobutane-1,2-dicarboxylic acid diethyl ester 
• 89615-28-1 (6aR,6bR,12bR,12cR)-6a,6b,12b,12c-Tetrahydro-5,8-dioxa-dibenzo[a,i]biphenylene-6,7-dione 

Relevant academic research and scientific papers

A new type of C2-symmetric bisphospine ligands with a cyclobutane backbone: Practical synthesis and application

(Matrix presented) A highly efficient and practical optical resolution of anti-head-to-head racemic coumarin dimer, (±)-5, by molecular complexation with TADDOL (6) through hydrogen bonding and a convenient transformation of enantiopure 5 to a new type of C2-symmetric bisphosphine ligand (3) have been achieved. The asymmetric induction efficiency of these chiral bisphosphine ligands was evaluated in Pd-catalyzed asymmetric allylic substitution, affording the allylic substitution products in excellent yield (up to 99%) and enantioselectivity (up to 98.9% ee).