1421961-56-9

Upstream product

• 170291-52-8 tert-butyl 4-(4-fluorophenyl)-4-(hydroxymethyl)piperidine-1-carboxylate 
• 160376-79-4 (4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methanol 
• 1377575-03-5 2-(chloromethyl)-6-cyclopropyl-4-(trifluoromethyl)pyridine 
• 22123-14-4 2-chloro-6-methyl-4-(trifluoromethyl)pyridine 
• 644981-89-5 1-(tert-butoxycarbonyl)-4-(4-fluorophenyl)piperidine-4-carboxylic acid 
• 1421961-54-7 2-hydroxymethyl-6-cyclopropyl-4-(trifluoromethyl)pyridine benzenesulfonic acid salt 
• 1421961-62-7 C₁₀H₁₀F₃NO 
• 1377575-02-4 C₁₀H₁₀F₃NO 
• 1421961-55-8 2-chloromethyl-6-cyclopropyl-4-(trifluoromethyl)pyridine p-toluenesulfonic acid salt 
• 1429661-32-4 C₁₉H₂₆FNO₄ 

Relevant academic research and scientific papers

Development of a scalable route to a dual NK-1/serotonin receptor antagonist

The evolution of a process for the preparation of a new heterocyclic dual NK1/serotonin receptor antagonist is described. The final synthesis features a telescoped sequence in which an iron(III)-catalyzed Grignard coupling is followed by a benzylic chlori