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| CAS No.: | 1422-07-7 |
|---|---|
| Name: | CODEINE HYDROCHLORIDE |
| Article Data: | 1 |
| Molecular Structure: | |
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|
|
| Formula: | C18H21NO3•ClH |
| Molecular Weight: | 335.831 |
| Synonyms: | CODEINE HYDROCHLORIDE DIHYDRATE |
| Density: | g/cm3 |
| Melting Point: | ~280° with some decompn |
| Boiling Point: | 462°Cat760mmHg |
| Flash Point: | 233.2°C |
| Safety: | Poison by ingestion, subcutaneous, intravenous, intraperitoneal and parenteral routes. An addictive drug. See also CODEINE. When heated to decomposition it emits very toxic fumes of NOx and HCl. |
| PSA: | 41.93000 |
| LogP: | 2.24100 |
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Chemistry
Product Name: Codeine hydrochloride (CAS NO.1422-07-7)
Molecular Formula: C18H22ClNO3
Molecular Weight: 335.83g/mol
Mol File: 1422-07-7.mol
Einecs: 215-829-5
Boiling point: 462 °C at 760 mmHg
Storage Temperature:
Flash Point: 233.2 °C
Enthalpy of Vaporization: 76.18 kJ/mol
Vapour Pressure: 2.47E-09 mmHg at 25°C
H-Bond Donor: 2
H-Bond Acceptor: 4
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 115mg/kg (115mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 873, 1975. | |
| mouse | LD50 | intravenous | 67mg/kg (67mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 16, Pg. 209, 1961. | |
| mouse | LD50 | oral | 365mg/kg (365mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 16, Pg. 209, 1961. | |
| mouse | LD50 | subcutaneous | 270mg/kg (270mg/kg) | Journal of Medicinal Chemistry. Vol. 19, Pg. 1054, 1976. | |
| rabbit | LD50 | intravenous | 67mg/kg (67mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 132, Pg. 255, 1961. |
| rabbit | LD50 | subcutaneous | 52mg/kg (52mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 66, Pg. 182, 1939. |
| rat | LD50 | intraperitoneal | 72400ug/kg (72.4mg/kg) | United States Patent Document. Vol. #4840949, | |
| rat | LD50 | intravenous | 67mg/kg (67mg/kg) | French Medicament Patent Document. Vol. #683M, | |
| rat | LD50 | subcutaneous | 145mg/kg (145mg/kg) | French Medicament Patent Document. Vol. #683M, | |
| rat | LD50 | unreported | 190mg/kg (190mg/kg) | BEHAVIORAL: ANALGESIA | Pharmacological Research Communications. Vol. 5, Pg. 175, 1973. |
Safety Profile
Poison by ingestion, subcutaneous, intravenous, intraperitoneal and parenteral routes. An addictive drug. See also CODEINE. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Specification
Codeine hydrochloride ,its CAS NO. is 1422-07-7,the synonyms is Codeine HCl ; Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, hydrochloride .