1422017-53-5Relevant academic research and scientific papers
Enantioselective total synthesis of (+)-colletoic acid via catalytic asymmetric intramolecular cyclopropanation of an α-diazo-β-keto diphenylphosphine oxide
Sawada, Takashi,Nakada, Masahisa
, p. 1004 - 1007 (2013)
The enantioselective total synthesis of (+)-colletoic acid, a potent naturally occurring 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, is described. This total synthesis features a highly enantioselective catalytic asymmetric intramolecular cyclopropanation of an α-diazo-β-keto diphenylphosphine oxide and five highly stereoselective reactions (cyclopropane opening, Diels-Alder reaction, iodolactonization, alkene formation, and reduction of α,β-unsaturated carboxylic acid).
Epoxy-Tethered Diels-Alder Reaction toward the Tricyclic Core of Kalihinols
Krishna Chaitanya, Nandikolla,Dinda, Shrabani,Mainkar, Prathama S.,Chandrasekhar, Srivari
supporting information, p. 3557 - 3560 (2020/04/30)
A chiral-template-driven intramolecular Diels-Alder reaction has been used to build the tricyclic core of kalihinols, a group of antimalarial marine natural products. The key starting materials are commercially available nerol and sulcatone.
