1422023-30-0Relevant articles and documents
Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: Chemistry, biological activity and pharmacology
Adachi, Hayamitsu,Nakae, Koichi,Sakamoto, Shuichi,Nosaka, Chisato,Atsumi, Sonoko,Shibuya, Masabumi,Higashi, Nobuaki,Nakajima, Motowo,Irimura, Tatsuro,Nishimura, Yoshio
, p. 60 - 71 (2018)
Microbial metabolites have attracted increasing interest as a source of therapeutics and as probes for biological mechanisms. New microbial metabolites and derivatives targeted at inflammation and bone disease therapy have been identified by focusing on prostaglandin release, osteoblast differentiation and immune cell functions. These modulators of inflammatory processes and bone disease contribute to our understanding of biological mechanisms and support identification of the therapeutic potential of drug lead candidates. The present review describes recent advances in the chemistry and analysis of inhibitors of prostaglandin release or other functional molecules of immune cells, as well as inducers of osteoblast differentiation, including biological and pharmacological activities.
Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases
Adachi, Hayamitsu,Nosaka, Chisato,Atsumi, Sonoko,Nakae, Koichi,Umezawa, Yoji,Sawa, Ryuichi,Kubota, Yumiko,Nakane, Chie,Shibuya, Masabumi,Nishimura, Yoshio
, p. 734 - 742 (2021/07/25)
A series of analogs of vegfrecine, a natural quinone vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, was synthesized via oxidative amination of 2,5-dihydroxybenzamide with functionalized arylamine followed by ammonolysis and
Vegfrecine, an inhibitor of VEGF receptor tyrosine kinases isolated from the culture broth of Streptomyces sp.
Nosaka, Chisato,Adachi, Hayamitsu,Sawa, Ryuichi,Nakae, Koichi,Atsumi, Sonoko,Kinoshita, Naoko,Kubota, Yumiko,Igarashi, Masayuki,Sei, Yoshihisa,Yamaguchi, Kentaro,Shibuya, Masabumi,Nishimura, Yoshio,Akamatsu, Yuzuru
, p. 715 - 719 (2013/06/05)
A new inhibitor of VEGF receptor tyrosine kinases, vegfrecine (1), was isolated from the culture broth of Streptomyces sp. MK931-CF8. The molecular structure of 1 was determined by NMR and MS analysis combined with synthesis. Compound 1 showed potent inhi
