1422039-12-0

Basic information

• Product Name: C₁₀H₉BrF₂O₂Zn
• Synonyms: C₁₀H₉BrF₂O₂Zn
• CAS NO: 1422039-12-0
• Molecular Weight: 344.471
• Mol File: 1422039-12-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: C₁₀H₉BrF₂O₂Zn(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₉BrF₂O₂Zn(1422039-12-0)
• EPA Substance Registry System: C₁₀H₉BrF₂O₂Zn(1422039-12-0)

Safety Data

• Hazardous Substances Data: 1422039-12-0(Hazardous Substances Data)

Upstream product

• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 

Downstream Products

• 1422039-13-1 C₁₀H₉BrF₂O₂ 
• 1527473-00-2 methyl 4-[(4E)-2,2-difluoro-4-(methoxycarbonyl)-5-phenylpent-4-enyl]benzoate 
• 1527472-99-6 methyl 4-[(4E)-2,2-difluoro-5-phenylpent-4-enyl]benzoate 
• 1527472-98-5 methyl 4-[2,2-difluoro-2-(2-phenylcyclohex-2-en-1-yl)ethyl]-benzoate 
• 1527472-97-4 methyl 4-(2-cyclohex-2-en-1-yl-2,2-difluoroethyl)benzoate 
• 1527472-96-3 methyl 4-(4-bromo-2,2-difluoropent-4-enyl)benzoate 
• 1527472-95-2 methyl 4-(2,2-difluoro-4-methylpent-4-enyl)benzoate 

Relevant articles and documents

Copper-Catalyzed Coupling of Acyl Chlorides with gem-Difluorinated Organozinc Reagents via Acyl Dithiocarbamates

A cross-coupling of acyl chlorides with gem-difluorinated organozinc reagents affording difluorinated ketones is described. In the reaction, acyl chlorides are first treated with potassium dithiocarbamate to generate S-acyl dithiocarbamates, which couple with organozincs in the presence of a copper(I) catalyst.

Reactions of 1,1-difluoroalkylzinc halides with chlorinating reagents

Compounds bearing chlorodifluoromethyl group can be assembled from organozinc chlorides, (chlorodifluoromethyl)trimethylsilane (Me3SiCF2Cl), and sulfuryl chloride as a chlorine source. Reactions of 1,1-difluoro-substituted organozinc bromides (RCF2ZnBr) with different chlorinating reagents lead to predominant or partial formation of the products bearing bromodifluoromethyl group.

Coupling of gem-difluorinated organozinc reagents with S-electrophiles

gem-Difluorinated organozinc reagents, which were prepared by insertion of CF2-fragment into C[sbnd]Zn bond, couple with diethyl dixanthogen, di(benzothiazolyl) disulfide, and tetraethylthiuram disulfide. The reaction is promoted either by a copper(I) catalyst or by irradiation with blue light in the presence of Eosin Y disodium salt.