142210-40-0Relevant academic research and scientific papers
Method for preparing a substituted perhydroisoindole
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, (2008/06/13)
PCT No. PCT/FR98/01405 Sec. 371 Date Mar. 20, 2000 Sec. 102(e) Date Mar. 20, 2000 PCT Filed Jul. 1, 1998 PCT Pub. No. WO99/01430 PCT Pub. Date Jan. 14, 1999The present invention relates to a process for the industrial synthesis of a substituted perhydroisoindole of formula (I): and of pharmaceutically acceptable salts thereof. The compound of formula (I) and its addition salts have especially valuable pharmacological properties. It is a very powerful secretor of insulin, which makes it useful in the treatment of non-insulin-dependent diabetes.
HYDROXYAZIDO DERIVATIVES AND RELATED COMPOUNDS AS RENIN INHIBITORS
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, (2008/06/13)
Novel compounds useful as renin inhibitors are provided. The compounds are hydroxyazido derivatives having the structural formula STR1 wherein the substituents R 1 through R 7 are as defined herein. Analogs of these compounds which are ketozaido derivatives are also provided. Additionally disclosed re methods for using the novel compounds to treat hypertension, and pharmaceutical compositions containing the compounds. Of particular interest are formulations for oral administration.
