1422180-08-2

Upstream product

• 399-52-0 5-fluoro-1H-indole 
• 100-51-6 benzyl alcohol 
• 67335-20-0 3,3'-(phenylmethylene)bis(1-methyl-2-phenyl-1H-indole) 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Facile access to bis(indolyl)methanes by copper-catalysed alkylation of indoles using alcohols under air

Bis(3-indolyl)methanes (BIM) are important and present in the structure of many alkaloid and bioactive compounds (anti-inflammatory, anticancer, antiobesity, antimicrobial, etc.). Herein, we have reported an air stable and convenient Cu(OAc)2 c

FeCl3·6H2O as a Mild Catalyst for Nucleophilic Substitution of Symmetrical Bis(indoyl)methanes

In this paper, unsymmetrical bis(indolyl)methane (BIM) and 3-alkylindole derivatives are smoothly synthesized from symmetrical BIMs with a variety of nucleophiles including heteroaromatic/aromatic compounds, allylsilane and alkynylsilane. FeCl3·6H2O is found to be a mild and highly effective catalyst for this nucleophilic substitution reaction in which N-methyl-2-phenylindole behaves as a good leaving group in the Csp3-Csp2 bond cleavage reaction. The operational ease, nonexpensive and environmentally friendly catalyst, mild reaction conditions, broad functional group tolerance, and scalability of this reaction strategy are advantages of the present procedure.

Magnetically recyclable CuFe2O4 catalyst for efficient synthesis of bis(indolyl)methanes using indoles and alcohols under mild condition

Bis(3-indolyl)methanes (BIM) are highly valuable and appear in the core structure of many natural products and pharmacologically active compounds (anticancer, anti-inflammatory, antiobesity, antimetastatic, antimicrobial, etc.). Herein, we have disclosed

L-Proline catalyzed multicomponent one-pot synthesis of gem-diheteroarylmethane derivatives using facile grinding operation under solvent-free conditions at room temperature

An efficient and straightforward l-proline catalyzed one-pot synthesis of a series of biologically relevant gem-(β-dicarbonyl)arylmethanes has been developed via a three-component reaction between indoles, aldehydes and C-H activated acids by grinding the

Pd-catalyzed C-H activation in water: Synthesis of bis(indolyl)methanes from indoles and benzyl alcohols

A method for the synthesis of bis(indolyl)methanes via palladium-catalyzed domino reactions of indoles with benzyl alcohols was developed. This protocol involves C3-benzylation of indoles and benzylic C-H functionalization in water. The Royal Society of Chemistry 2013.