1422237-46-4Relevant academic research and scientific papers
3-Bromooxindoles as nucleophiles in asymmetric organocatalytic Mannich reactions with N-Ts-imines
Li, Jianhao,Du, Taiping,Zhang, Gang,Peng, Yungui
supporting information, p. 1330 - 1332 (2013/03/13)
A direct asymmetric Mannich reaction of N-unprotected 3-bromooxindoles with N-Ts-imines catalyzed by bifunctional thiourea derived from 2-substituted cinchona alkaloid was developed. Products with vicinal chiral tertiary and brominated quaternary stereogenic centers were achieved in excellent diastereo- and enantioselectivity (up to 99:1 dr, 99% ee).
