1422237-71-5

Upstream product

• 1422237-46-4 N-((S)-((R)-3-bromo-2-oxoindolin-3-yl)(phenyl)methyl)-4-methylbenzenesulfonamide 
• 22942-87-6 3-bromo-1,3-dihydro-2H-indol-2-one 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 

Relevant academic research and scientific papers

3-Bromooxindoles as nucleophiles in asymmetric organocatalytic Mannich reactions with N-Ts-imines

A direct asymmetric Mannich reaction of N-unprotected 3-bromooxindoles with N-Ts-imines catalyzed by bifunctional thiourea derived from 2-substituted cinchona alkaloid was developed. Products with vicinal chiral tertiary and brominated quaternary stereogenic centers were achieved in excellent diastereo- and enantioselectivity (up to 99:1 dr, 99% ee).