1422284-64-7

Basic information

• Product Name: C₁₂H₈F₃NO₃
• CAS NO: 1422284-64-7
• Molecular Weight: 271.196
• Mol File: 1422284-64-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₂H₈F₃NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₈F₃NO₃(1422284-64-7)
• EPA Substance Registry System: C₁₂H₈F₃NO₃(1422284-64-7)

Safety Data

• Hazardous Substances Data: 1422284-64-7(Hazardous Substances Data)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 1352934-53-2 4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)quinoline-2-carbonitrile 
• 1352934-52-1 4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)quinoline-2-carboxamide 
• 1422284-65-8 C₂₀H₁₆F₃NO₄ 
• 1444310-04-6 1,4-dihydro-N′-(3-hydroxy-2-cyclohexenylidene)-4-oxo-6-trifluoromethylquinoline-2-carbohydrazide 
• 1444310-02-4 1,4-dihydro-4-oxo-(N′-phenylcarbamoyl)-6-trifluoromethylquinoline-2-carbohydrazide 

Relevant articles and documents

Quinolone analogues 12: Synthesis and tautomers of 2-substituted 4-quinolones and related compounds

The 4-quinolone-2-carboxylates 4a,b were converted into the 4-quinolone-2-carbohydrazides 5a,b, hydrazones 6,7,10, and related compounds 8,9,11. The 4-methoxyquinoline-2-carboxylate 12 was also transformed into the 4-methoxyquinoline-2-carbohydrazide 13, which was modified to the hydrazone 14 and related compound 15. The antimicrobial activities of compounds 6b and 14 are described together with the 4-oxo and 4-hydroxy tautomers of compounds 4-11 in deuteriodimethyl sulfoxide and deuteriotrifluoroacetic acid.

Divergent Synthesis of Quinolones and Dihydroepindolidiones via Cu(I)-Catalyzed Cyclization of Anilines with Alkynes

A unique and efficient method for one-pot synthesis of diverse 4-quinolones from simple and readily available primary anilines and alkynes via Cu(I)-catalyzed direct cyclization has been developed. The (thio)phenols were also found to visible substrates for this reaction. Moreover, an unprecedented synthesis of dihydroepindolidiones has been demonstrated by using secondary anilines as the versatile substrates.

Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders

4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C 1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II STR1 wherein R 2 represents carboxy or a group convertible thereto in vivo, R 6 is hydrogen and R 5 and R 7 represent C 1-6 alkyl or halogen, provided that R 5 and R 7 are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.