1422285-71-9

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 100-97-0 hexamethylenetetramine 
• 34969-79-4 2-bromo-1-(3,5-dibromo-4-hydroxyphenyl)ethanone 
• 2887-72-1 1-(3,5-dibromo-4-hydroxyphenyl)ethan-1-one 

Downstream Products

• 1422285-76-4 C₁₈H₁₄Br₃NO₅ 
• 1422285-77-5 C₁₈H₁₃Br₃N₂O₃ 
• 1422285-78-6 C₁₈H₁₂Br₃ClN₂O₂ 
• 1422285-79-7 C₂₃H₂₃Br₃ClN₃O₂ 
• 1422285-80-0 C₂₂H₂₁Br₃ClN₃O₂ 
• 1422285-81-1 C₂₁H₁₇Br₄ClN₂O₂ 
• 1422285-73-1 C₈H₈Br₂NO₂⁽¹⁺⁾*Br^(1-) 

Relevant academic research and scientific papers

The first total synthesis and biological evaluation of marine natural products ma'edamines A and B

We have developed the first total syntheses of marine natural products ma'edamines A (18) and B (20). Structurally, they contain a pyrazine-2-(1H)-one core and were screened for antiproliferative activity on several cancer cell lines. Out of the six cell lines tested, ma'edamines A and B showed significant cytotoxicity against human colon cancer line COLO 205 (IC50 7.9 and 10.3 μM, respectively), breast cancer cell line MCF-7 (IC50: 6.9 and 10.5 μM, respectively) and human lung adenocarcinoma cell line A549 (IC50: 12.2 and 15.4 μM, respectively). The apoptotic effect of ma'edamines was confirmed by comet assay. Hence ma'edamines are likely to be useful as leads for development of a new class of anti-cancer agents.