142229-22-9Relevant academic research and scientific papers
Routes to 4-Substituted Analogues of the Glycine/NMDA Antagonist HA-966. Enantioselective Synthesis of (3R,4R) 3-Amino-1-Hydroxy-4-Methyl-2-Pyrrolidinone (L-687,414).
Rowley, Michael,Leeson, Paul D.,Williams, Brian J.,Moore, Kevin W.,Baker, Raymond
, p. 3557 - 3570 (2007/10/02)
Glycine anion (4) and glycine cation (8) synthons are used in efficient synthesis of 4-substituted analogues of HA-966 (1).A stereospecific route to cis derivatives involves hydrogenation of enamines such as 16.Introduction of a chiral auxiliary leads to
