142229-18-3

Upstream product

• 127793-62-8 4-((tert-butyldiphenylsilyl)oxy)butanal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 142229-34-3 1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-hydroxy-2-pyrrolidinone 
• 142229-32-1 iso-propyl 5-tert.-butyldiphenylsilyloxy-2-hydroxy-3-hydroxyliminomethylpentanoate 
• 142229-17-2 4-tert.-butyldiphenylsilyloxybutanal oxime 
• 132047-92-8 tert-butyl(pent-4-en-1-yloxy)diphenylsilane 
• 142229-36-5 1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole 

Downstream Products

• 142229-39-8 cis 1-benzyloxy-4-(2-hydroxyethyl)-3-(4-methoxybenzylamino)-2-pyrrolidinone 
• 142229-37-6 cis 3-amino-1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-2-pyrrolidinone 
• 142229-19-4 cis 3-benzyloxy-6-(4-methoxybenzyl)-4-oxo-3,6-diazabicyclo<3.3.0>octane 
• 142229-21-8 cis 1-benzyloxy-3-tert.-butyloxycarbonylamino-4-(2-hydroxyethyl)-2-pyrrolidinone 
• 142229-22-9 cis 1-benzyloxy-3-tert.-butyloxycarbonylamino-4-hydroxymethyl-2-pyrrolidinone 
• 142229-38-7 cis 1-benzyloxy-3-tert.-butyloxycarbonylamino-4-vinyl-2-pyrrolidinone 

Relevant academic research and scientific papers

Routes to 4-Substituted Analogues of the Glycine/NMDA Antagonist HA-966. Enantioselective Synthesis of (3R,4R) 3-Amino-1-Hydroxy-4-Methyl-2-Pyrrolidinone (L-687,414).

Glycine anion (4) and glycine cation (8) synthons are used in efficient synthesis of 4-substituted analogues of HA-966 (1).A stereospecific route to cis derivatives involves hydrogenation of enamines such as 16.Introduction of a chiral auxiliary leads to