14223-44-0

Upstream product

• 10468-64-1 o-tolyl isocyanide 
• 64-18-6 formic acid 
• 95-53-4 o-toluidine 
• 94-69-9 2'-methylformanilide 

Downstream Products

• 16518-81-3 o-tolyl-selenourea 
• 16519-44-1 N,N'-di-o-tolylselenourea 
• 51314-50-2 N-(2-methyphenyl)-1H-benzo[d]imidazol-2-amine 
• 1332566-34-3 5-amino-3-phenyl-2-selenoxo-N,1-di(2-tolyl)-2,3-dihydro-1H-imidazole-4-carboselenoamide 
• 1332566-39-8 5-amino-3-methyl-2-selenoxo-N,1-di(2-tolyl)-2,3-dihydro-1H-imidazole-4-carboselenoamide 
• 1415118-15-8 (E)-4-(iodomethyl)-2-(2-methylphenylimino)-1,3-thiaselenolane 
• 1415118-06-7 S-allyl-N-(2-methylphenyl)-selenothiocarbamate 
• 1434817-60-3 O-ethyl-N-(o-methylphenyl)selenocarbamate 
• 10532-63-5 N-(o-tolyl)cyanamide 
• 1429333-36-7 2-(2-methylphenylimino)-1,3-thiaselenane 
• 1429333-50-5 3-(2-methylphenyl)-1,3-thiazinane-2-selenone 
• 1429333-37-8 2-(2-methylphenylimino)-1,3-thiaselenane 
• 1401253-20-0 3-(4-methoxyphenyl)-5-(2-methylphenylamino)-1,3,4-selenadiazol-2(3H)-one 
• 1401253-18-6 3-(4-chlorophenyl)-5-(2-methylphenylamino)-1,3,4-selenadiazol-2(3H)-one 

Relevant academic research and scientific papers

Synthesis of selenazolopyridine derivatives with capability to induce apoptosis in human breast carcinoma MCF-7 cells through scavenge of intracellular ROS

A series of selenazolopyridine derivatives have been synthesized and characterized by X-ray diffraction, high resolution NMR and Mass spectrum. The in vitro anticancer activities of the synthetic compounds were screened against a panel of human cancer cell lines, human breast carcinoma MCF-7 cells, human liver carcinoma HepG2 cells and L02 normal cell line by MTT assay. By analyzing the structure-activity relationship among the synthetic compounds, it was found that 2-(phenylamino) selenazolo [5,4-b] pyridine, (PSeD, 7) had higher growth inhibitory effect on MCF-7 cells. The intracellular mechanism of cell death was evaluated by flow cytometric analysis and ROS assay, which revealed that PSeD could induce MCF-7 cells apoptosis by scavenging intracellular ROS. Taken together, we regard PSeD as an antioxidant which could inhibit cancer cell growth through induction of apoptosis.

Efficient synthesis of 4H-benzo[d][1,3]oxazin-4-ones from anthranilic acids and aryl isoselenocyanates

A synthesis in good to excellent yields of 23 4H-benzo[d][1,3]oxazin-4- ones, 18 of which are novel, from monosubstituted anthranilic acids and variously substituted phenyl isoselenocyanates without using any harsh reagents has been developed. The Se powder precipitated during the reaction could be efficiently recycled for the preparation of the aryl isoselenocyanates.

Synthesis of sugar-derived isoselenocyanates, selenoureas, and selenazoles

Aryl, alkyl, and sugar-derived isoselenocyanates were prepared by a one-pot procedure starting from the corresponding formamides, using triphosgene as a dehydrating agent, triethylamine, and black selenium powder. The preparation of sugar selenoureas by coupling of O-protected sugar-derived isoselenocyanates with different amines, and by coupling of unprotected glycopyranosyl amines with phenyl isoselenocyanate was also accomplished. The synthesis of a glucopyranos-2-yl-selenazole starting from O-protected 2-amino-2-deoxy-d-glucose by coupling with benzoyl isoselenocyanate, Se-alkylation with phenacyl bromide, and acid-catalyzed dehydration is also reported. Unprotected N-(β-d-glucopyranosyl)-N′-phenylselenourea was transformed into a 1,2-trans-fused bicyclic isourea upon treatment with aqueous hydrogen peroxide; the same isourea was prepared by a one-pot three-step procedure from β-d-glycopyranosylamine by thiophosgenation, coupling with aniline, and HgO-mediated desulfurization.

An efficient and convenient route to some isoselenocyanates via reaction of formamides with bis(trichloromethyl)carbonate and selenium

A class of isoselenocyanates was synthesized via one-pot procedure of N-substituted formamides with selenium and bis(trichloromethyl)carbonate in the presence of triethylamine in good yields.