1422347-11-2

Upstream product

• 1163245-33-7 C₃₁H₄₁NO₃Si 
• 126822-71-7 1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 
• 187458-29-3 (2S, 3S)-5-(tert-butyldiphenylsilyloxy)-3-methylpentane-1,2-diol 
• 169387-99-9 (S)-2-methyl-4-(tert-butyldiphenylsilyloxy)butanol 
• 112897-03-7 3-(tert-butyldiphenylsilyloxy)-1-propanal 
• 127047-71-6 3-(tert-butyldiphenylsilyloxy)propan-1-ol 
• 127665-77-4 (E)-5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-en-1-ol 

Downstream Products

• 1422347-12-3 (4S,7S,E)-9-(tert-butyldiphenylsilyloxy)-5,7-dimethylnona-1,5-dien-4-ol 
• 1422347-14-5 ((E,3S,6S)-6-methoxy-3, 5-dimethylnona-4, 8-dienyloxy)(tert-butyl)diphenylsilane 
• 1422347-17-8 (S,E)-ethyl 6-(tert-butyldiphenylsilyloxy)-2,4-dimethylhex-2-enoate 
• 1422347-13-4 (4R,7S,E)-9-(tert-butyldiphenylsilyloxy)-5,7-dimethylnona-1,5-dien-4-ol 
• 1422347-16-7 (3S,6S,E)-6-methoxy-3, 5-dimethylnona-4,8-dien-1-ol 

Relevant academic research and scientific papers

Stereoselective Total Synthesis of Bioactive Marine Natural Product Biselyngbyolide B

A convergent strategy for the stereoselective total synthesis of biologically active marine natural product biselyngbyolide B has been developed. Key strategies of this synthesis include Jamison protocol of trans-hydroalumination/allylation for installation of C18-C23 olefin moiety and intramolecular Heck coupling for macrocyclization.

Synthetic Studies on Alotamide A: Construction of N-Demethylalotamide A

Several approaches to the synthesis of cyclodepsipeptide natural product alotamide A are described, eventually affording a very advanced N-demethylated analogue of the targeted natural product. The difficulties found in our endeavors on the synthesis of alotamide A have allowed us to gather some valuable information regarding the most convenient synthetic step for each key transformation. The intramolecular Csp2?Csp2 Stille cross-coupling and the macrolactam formation were found to be reliable protocols for the final construction of the alotamide A skeleton.

Enantioselective synthesis of the C5-C23 segment of biselyngbyaside

Stereo and enantioselective synthesis of C5-C23 fragment of cytotoxic marine natural product biselyngbyaside is achieved using E-selective methyl lithium addition onto enyne, Crimmin's acetate aldol reaction, Sharpless asymmetric epoxidation, and Julia-Kocienski olefination as the key steps.