1422358-64-2Relevant academic research and scientific papers
Influence of carboxylic acid functionalities in ruthenium (II) polypyridyl complexes on DNA binding, cytotoxicity and antioxidant activity: Synthesis, structure and in vitro anticancer activity
Sathiya Kamatchi, Thangavel,Chitrapriya, Nataraj,Kim, Seog K.,Fronczek, Frank R.,Natarajan, Karuppannan
, p. 253 - 264 (2013)
Four new Ru(II) complexes [RuHCl(bpy)(PPh3)(CO)] (1), [RuHCl(bpy)(AsPh3)(CO)] (2) (bpy = 2,2′-bipyridine), [RuCl(HL)(PPh3)2(CO)] (3) and [RuCl(HL)(AsPh 3)2(CO)] (4) (HL = 2,2′-bipyridine-4,4′- dicarboxylic acid) were synthesized and characterized. X-ray diffraction was used to characterize 3 in solid state. The interactions of these complexes with DNA were explored by different techniques which revealed that the complexes could bind to CT-DNA through non-intercalation. The in vitro cytotoxic and antioxidant activities of the complexes validated against a panel of cancer cell lines and free radicals showed that 3 and 4 possess quite high anticancer and antioxidant activities over 1, 2 and standard drugs. An apparent dependence of biological activities on incorporation of COOH in bipyridine moiety was noticed: Inclusion of COOH caused significant differences in DNA binding, cytotoxicity and antioxidant activity.
