1422370-75-9Relevant academic research and scientific papers
Carbometalation-carboxylation of 2,3-allenols with carbon dioxide: A dramatic effect of halide anion
Li, Suhua,Miao, Bukeyan,Yuan, Weiming,Ma, Shengming
supporting information, p. 977 - 979 (2013/04/10)
The cyclic organometallic intermediates formed via CuCl-mediated highly regio- and stereoselective carbomagnesiation of 2,3-allenols with Grignard reagents may smoothly react with carbon dioxide to afford 2(5H)-furanones. A dramatic effect of the halide anion from the Grignard reagent (Br vs Cl) for CO2 activation was observed. The reaction proceeded smoothly under mild conditions to afford the products in 58-93% yields.
