1422446-87-4

Upstream product

• 1440425-91-1 5-methyl-2-(trifluoromethyl)-5H-indolo[2,3-b]quinolin-11(6H)-one 
• 942-24-5 3-methoxycarbonylindole 
• 1440425-85-3 methyl 2-(methyl(4-(trifluoromethyl)phenyl)amino)-1Hindole-3-carboxylate 
• 152812-42-5 methyl 2-chloro-1H-indole-3-carboxylate 
• 1356825-66-5 11-chloro-5-methyl-2-(trifluoromethyl)-5H-indolo[2,3-b]quinoline 

Relevant academic research and scientific papers

indole quinoline derivative, wherein the derivative, and containing said derivative antimalarial agent and an anti-cancer agent

PROBLEM TO BE SOLVED: To provide a compound capable of becoming an effective component of an antimalarial agent with a high antimalarial activity and high safety (particularly effective also against chloroquine resistant malaria protozoa), and capable of becoming an effective component of an anticancer agent with high antitumor activity and low toxicity to normal cells.SOLUTION: There is provided an indolequinoline derivative (A) shown by formula (A) or a pharmaceutically allowable salt thereof.

Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines

To obtain a high antimalarial activity with neocryptolepine derivatives, modifying and changing the side chains at the C11 position with varying the substituents of an electron-withdrawing or electron-donating nature at the C2 position for a SAR study wer