142246-63-7

Basic information

• Product Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
• Synonyms: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE;5-FLUORO-DU CEP;5-fluorodeoxyuridine-ce*phosphoramidite for abi;5-FLUORODEOXYURIDINE-CE PHOSPHORAMIDITE FOR CYCLONE;N-blocked-5'-O-DMT CED fluorodeoxyuridine phosphoramidite;5'-DMT-5-F-2'-dU Phosphoramidite
• CAS NO: 142246-63-7
• Molecular Formula: C39H46FN4O8P
• Molecular Weight: 748.78
• Mol File: 142246-63-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Store at -20°C
• CAS DataBase Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(142246-63-7)
• EPA Substance Registry System: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(142246-63-7)

Safety Data

• Hazardous Substances Data: 142246-63-7(Hazardous Substances Data)

Usage

Uses

5''-O-[Bis(4-methoxyphenyl)phenylmethyl]-2''-deoxy-5-fluoro-uridine 3''-[2-cyanoethylbis(1-methylethyl)phosphoramidite] is a nucleoside analog that may be effective in the treatment of breast cancer by influencing the expression of HER-2.

Upstream product

• 104495-48-9 1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 50-91-9 5-Fluoro-2'-deoxyuridine 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 

Relevant articles and documents

ON-DEMAND PHOSPHORAMIDITE SYNTHESIS

The invention relates to a method of synthesis of phosphoramidites by immobilization of a phosphitylation agent on a resin activated to create a charged resin, then putting in contact with the charged resin with a suitable substrate. Phosphoramidites are synthesized in a few minutes from the application of the starting materials. Thus, the process makes it possible to create specific phosphoramidites on demand when they are needed in other applications. The substrates to be applied are mainly nucleosides, thus making it possible to create nucleoside phosphoramidites for the subsequent synthesis of oligonucleotides.

Enhancing antitumor efficacy of nucleoside analog 5-fluorodeoxyuridine on her2-overexpressing breast cancer by affibody-engineered DNA nanoparticle

Background: Chemotherapy, as an adjuvant treatment strategy for HER2-positive breast cancer, can effectively improve clinical symptoms and overcome the drug resistance of therapeutic monoclonal antibodies. Nucleoside analogues are a class of traditional c

Floxuridine Homomeric Oligonucleotides “Hitchhike” with Albumin In Situ for Cancer Chemotherapy

Automated attachment of chemotherapeutic drugs to oligonucleotides through phosphoramidite chemistry and DNA synthesis has emerged as a powerful technology in constructing structure-defined and payload-tunable oligonucleotide–drug conjugates. In practice,