14225-76-4

Basic information

• Product Name: 2-(2-CHLORO-PHENYL)-5-METHYL-1H-BENZOIMIDAZOLE
• Synonyms: 2-(2-CHLORO-PHENYL)-5-METHYL-1H-BENZOIMIDAZOLE;2-(2-Chlorophenyl)-5-MethylbenziMidazole, 95%
• CAS NO: 14225-76-4
• Molecular Formula: C₁₄H₁₁ClN₂
• Molecular Weight: 242.7035
• Mol File: 14225-76-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 439.5°Cat760mmHg
• Flash Point: 252.2°C
• Appearance: /
• Density: 1.286g/cm³
• Vapor Pressure: 6.36E-08mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: 2-(2-CHLORO-PHENYL)-5-METHYL-1H-BENZOIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLORO-PHENYL)-5-METHYL-1H-BENZOIMIDAZOLE(14225-76-4)
• EPA Substance Registry System: 2-(2-CHLORO-PHENYL)-5-METHYL-1H-BENZOIMIDAZOLE(14225-76-4)

Safety Data

• Hazardous Substances Data: 14225-76-4(Hazardous Substances Data)

Usage

General Description

2-(2-chloro-phenyl)-5-methyl-1H-benzimidazole is a chemical compound with the molecular formula C14H11ClN2. It is a benzimidazole derivative with a chlorine atom on the 2-position of the phenyl ring and a methyl group on the 5-position of the benzimidazole ring. 2-(2-CHLORO-PHENYL)-5-METHYL-1H-BENZOIMIDAZOLE has potential pharmaceutical properties and has been studied for its inhibitory effects on certain enzymes and receptors. It may also have applications in the development of new drugs for the treatment of various diseases.

InChI:InChI=1/C14H11ClN2/c1-9-6-7-12-13(8-9)17-14(16-12)10-4-2-3-5-11(10)15/h2-8H,1H3,(H,16,17)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 45743-05-3 2-chlorobenzimidamide 
• 5720-05-8 4-methylphenylboronic acid 
• 326903-05-3 2-chloro-benzoic acid-(4-methyl-2-nitro-anilide) 

Relevant articles and documents

A simple and efficient procedure for the synthesis of benzimidazoles using trichloroisocyanuric acid (TCCA) as the oxidant

(Chemical Equation Presented) A Direct one step synthesis of various benzimidazoles from 3,4-diaminotoluene and benzaldehydes is described using TCCA as the oxidant. The salient features of this method include simple procedure, mild condition, no waste pr

Solid Phase Synthesis of Biologically active Benzimidazole Derivatives Catalysed by CH3S03H-Si02 under Solvent free Condition

A simple an expeditious method was established for the synthesis of 2-Substituted-1H-Benzimidazole derivatives at 90°C using o-phenylenediamine and different aldehydes. It has been found that a mixture of Methanesulphonic acid-Si02to be an effective catal

Copper catalyzed N-arylation of amidines with aryl boronic acids and one-pot synthesis of benzimidazoles by a Chan-Lam-Evans N-arylation and C-H activation/C-N bond forming process

Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu(OAc) 2 and NaOPiv under mild aerobic conditions. Combining this step with an intramolecular direct C-H bond functionalization, catalyzed by the same catalytic system but under oxygen at 120 C, afforded benzimidazoles 3 in good to excellent yields.