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Usage

Uses

Used in Pharmaceutical Industry:
2-(2-CHLORO-PHENYL)-5-METHYL-1H-BENZOIMIDAZOLE is used as a pharmaceutical compound for its potential inhibitory effects on certain enzymes and receptors. Its unique structure and properties make it a candidate for the development of new drugs to treat a range of diseases by modulating biological targets.
Used in Drug Development Research:
In the field of drug development, 2-(2-CHLORO-PHENYL)-5-METHYL-1H-BENZOIMIDAZOLE serves as a research compound for studying its interactions with biological targets. This helps in understanding its mechanism of action and potential therapeutic applications, paving the way for the creation of novel therapeutic agents.

InChI:InChI=1/C14H11ClN2/c1-9-6-7-12-13(8-9)17-14(16-12)10-4-2-3-5-11(10)15/h2-8H,1H3,(H,16,17)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 45743-05-3 2-chlorobenzimidamide 
• 5720-05-8 4-methylphenylboronic acid 
• 326903-05-3 2-chloro-benzoic acid-(4-methyl-2-nitro-anilide) 

Relevant academic research and scientific papers

A simple and efficient procedure for the synthesis of benzimidazoles using trichloroisocyanuric acid (TCCA) as the oxidant

(Chemical Equation Presented) A Direct one step synthesis of various benzimidazoles from 3,4-diaminotoluene and benzaldehydes is described using TCCA as the oxidant. The salient features of this method include simple procedure, mild condition, no waste pr

A simple and efficient procedure for the synthesis of benzimidazoles using air as the oxidant

Direct one-step synthesis of various benzimidazoles from phenylenediamines and aldehydes is described using air as the oxidant. The salient features of this method include a simple procedure, mild conditions, no coupling agents or commercial oxidants/additives used, no waste produced (only by-product being water), easy purification, and high generality.

Solid Phase Synthesis of Biologically active Benzimidazole Derivatives Catalysed by CH3S03H-Si02 under Solvent free Condition

A simple an expeditious method was established for the synthesis of 2-Substituted-1H-Benzimidazole derivatives at 90°C using o-phenylenediamine and different aldehydes. It has been found that a mixture of Methanesulphonic acid-Si02to be an effective catal

Zn3(BTC)2 as a Highly Efficient Reusable Catalyst for the Synthesis of 2-Aryl-1H-Benzimidazole

Zn3(BTC)2 metal-organic frameworks as recyclable and heterogeneous catalysts were effectively used to catalyze the synthesis of benzimidazole derivatives from o-phenylendiamine and aldehydes in ethanol. This method provides 2-aryl-1H

Copper catalyzed N-arylation of amidines with aryl boronic acids and one-pot synthesis of benzimidazoles by a Chan-Lam-Evans N-arylation and C-H activation/C-N bond forming process

Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu(OAc) 2 and NaOPiv under mild aerobic conditions. Combining this step with an intramolecular direct C-H bond functionalization, catalyzed by the same catalytic system but under oxygen at 120 C, afforded benzimidazoles 3 in good to excellent yields.

A simple and efficient one-pot synthesis of 2-substituted benzimidazoles

A simple and efficient procedure for the synthesis of substituted benzimidazoles through a one-pot condensation of o-phenylenediamines with aryl aldehydes in the presence of H2O2/HCl system in acetonitrile at room temperature is described. Short reaction time, large-scale synthesis, easy and quick isolation of the products, and excellent yields are the main advantages of this procedure. Georg Thieme Verlag Stuttgart.