1422656-12-9Relevant academic research and scientific papers
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides
Gemma, Sandra,Kunjir, Sanil,Brindisi, Margherita,Novellino, Ettore,Campiani, Giuseppe,Butini, Stefania
, p. 1233 - 1235 (2013/03/13)
As a part of our work in the development of novel antimalarials, we were interested in elaborating an appropriate synthetic strategy for the preparation of endoperoxide-containing bridged bicyclic scaffolds. Through a TMSOTf-promoted dehydrative cyclization strategy we synthesized 2,3,8-trioxabicyclo[3,3,1] nonane endoperoxides. Alkyl substituents at C4 of the bicyclic scaffold could be readily introduced through exposure to Grignard reagents.
