1422740-01-9

Upstream product

• 1403826-32-3 ethyl (RS)-N-[(EZ)-4-(4-chlorophenyl)-3-cyano-7-methoxy-4H-chromen-2-yl]formimidate 
• 130944-03-5 2-Amino-4-(4-chloro-phenyl)-7-hydroxy-4H-chromene-3-carbonitrile 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 1422739-84-1 C₁₈H₁₅ClN₄O₂ 
• 326918-74-5 (RS)-2-amino-4-(4-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of novel chromene derivatives of expected antitumor activity

Inhibition of tubulin polymerization is one of the important tactics in cancer therapy. Since 4-aryl-4H-chromene derivatives are found to be microtubule-binding agents via interfering with tubulin polymerization so we decide to concentrate our exploration efforts on the combination of this nucleus with 5-, 6-, and/or 7-memebered heterocyclic moieties in a novel series of compounds to explore the effect that might result from this combination. Ten novel compounds were selected for anticancer screening assay against MCF-7 breast cancer cell line in comparison to colchicine as positive control and most of them showed excellent activity.