1422772-78-8

Basic information

• Product Name: 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid
• Synonyms: 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid
• CAS NO: 1422772-78-8
• Molecular Formula: C7H4BrN3O2
• Molecular Weight: 242.04
• Mol File: 1422772-78-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 2.068±0.06 g/cm3(Predicted)
• PKA: -3.11±0.30(Predicted)
• CAS DataBase Reference: 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid(1422772-78-8)
• EPA Substance Registry System: 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid(1422772-78-8)

Safety Data

• Hazardous Substances Data: 1422772-78-8(Hazardous Substances Data)

Usage

General Description

2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid is a chemical compound that belongs to the group of pyrrolopyrazines, which consist of pyrrole fused to a pyrazine. The systematic name for this compound is 3-bromo-1H-pyrrolo[2,3-b]pyrazine-2-carboxylic acid, indicating the presence of a carboxyl group. This chemical compound has potentially important applications in the field of organic synthesis and medicinal chemistry, although the specific properties and uses of this particular compound may still need to be explored. However, like many pyrrolopyrazines, it may exhibit biological activities that could be harnessed for pharmaceutical use.

Upstream product

• 1334674-88-2 (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol 
• 875781-41-2 5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine 
• 1185428-32-3 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde 
• 1334674-87-1 (2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol 
• 875781-43-4 2-bromo-5H-pyrrolo[2,3-b]pyrazine 

Downstream Products

• 1426425-97-9 N-(1-(tertbutyldimethylsilyloxy)-2-methylpropan-2-yl)-2-(6-fluoro-1-(3-(methylsulfonyl)propyl)-1Hindazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1426425-82-2 N-tert-butyl-2-(1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-6-fluoro-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1426425-95-7 N-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)-2-(6-fluoro-1-(3-hydroxybutyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1426425-94-6 N-(1-(tertbutyldimethylsilyloxy)-2-methylpropan-2-yl)-2-(6-fluoro-1-(3-oxobutyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1422773-06-5 N-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)-2-(6-fluoro-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1426425-83-3 N-tert-butyl-2-(6-fluoro-1-(3-(methylsulfonyl)propyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 

Relevant articles and documents

PYRROLOPYRIMIDINE ITK INHIBITORS

Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL, PYRROLO[2,3-B]PYRIDINYL ACRYLAMIDES AND EPOXIDES THEREOF

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3- b]pyrazinyl,and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides,and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention

PYRROLOPYRAZINE KINASE INHIBITORS

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.