1422841-72-2

Upstream product

• 1422842-08-7 4-(5-(4-bromophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine 
• 100397-96-4 1-(4-bromophenyl)-2-(pyridin-4-yl)ethanone 
• 192436-83-2 4-bromo-N-methoxy-N-methylbenzamide 
• 586-76-5 4-Bromobenzoic acid 
• 1422842-13-4 C₁₅H₁₃N₃S 
• 951122-48-8 2-Bromomethyl-7-methoxy-quinoline 
• 19490-87-0 7-methoxy-2-methylquinoline 

Relevant academic research and scientific papers

Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A

Twenty eight new analogues were synthesized by optimizing the structure of MP-10 and their in vitro binding affinities towards PDE10A, PDE3A/B, and PDE4A/B were determined. Among these new analogues, 10a, 10b, 10d, 11a, 11b and 11d are very potent towards PDE10A and have IC50 values of 0.40 ± 0.02, 0.28 ± 0.06, 1.82 ± 0.25, 0.24 ± 0.05, 0.36 ± 0.03 and 1.78 ± 0.03 nM respectively; these six compounds displayed high selectivity for PDE10A versus PDE3A/3B/4A/4B. The promising compounds will be further validated in vivo to identify PDE10A imaging tracers. The Royal Society of Chemistry.