14229-63-1

Usage

Classification

Psychoactive drug
Belongs to the synthetic cathinone derivatives group

Type

Stimulant
Produces effects similar to cocaine and amphetamine

Chemical structure

Phenethylamine backbone with a thioether group
Member of the cathinone family

Mechanism of action

Releasing agent for neurotransmitters
Serotonin, norepinephrine, and dopamine

Effects

Stimulating and euphoric
Increases the release of neurotransmitters in the brain

Risks

Adverse effects and addiction
Cardiovascular problems and psychological disturbances

Legal and health concerns

Restricted use and potential health risks
Associated with legal issues and potential negative health outcomes

Upstream product

• 67-68-5 dimethyl sulfoxide 
• 495-40-9 propiophenone 
• 13714-87-9 α-Mercapto-n-butyrophenon 
• 77-78-1 dimethyl sulfate 
• 20828-73-3 methylsulfanylium 
• 14313-57-6 α-Chlor-n-butyrophenon 
• 14229-71-1 5-ethyl-2,4-diphenyl-2-propyl-2,5-dihydro-thiazole 

Downstream Products

• 73951-65-2 trans-2-ethyl-3-phenyl-oxirane 
• 69262-89-1 R*,R*-2-methylthio-1-phenyl-butanol-1 
• 69262-89-1 (1S,2R)-2-Methylsulfanyl-1-phenyl-butan-1-ol 

Relevant academic research and scientific papers

Metal-Free Oxidative Esterification of Ketones and Potassium Xanthates: Selective Synthesis of α-Ketoesters and Esters

A novel and efficient oxidative esterification for the selective synthesis of α-ketoesters and esters has been developed under metal-free conditions. In the protocol, various α-ketoesters and esters are available in high yields from commercially available ketones and potassium xanthates. Mechanistic studies have proven that potassium xanthate not only promotes oxidative esterification but also provides an alkoxy moiety for the reaction, which involves the cleavage and reconstruction of C-O bonds.

Electrophilic substitutions with the electrogenerated sulfenium cation R1-S+

The sulfenium cation R1-S+ electrogenerated by oxidation of organic disulfides, reacts with phenols, aromatic ethers and ketones bearing an hydrogen atom in α position, to give alkyl (aryl) sulfanyl compounds.

A Facile One-Pot Synthesis of Vicinal Di- and Triketones from α-Methylene Ketones by NBS-DMSO Oxidation

The reaction of 1,2-diarylethanones (1a-u) with N-bromosuccinimide in anhydrous dimethyl sulphoxide afforded diarylethanediones (2a-u) in excellent yields.Under similar conditions, 1-phenyl-2-butanone (3) gave 1-phenyl-1,2-butanedione (4) in fair yield in addition to a small amount of 1-phenyl-3-methylthio-1,2-butanedione (5) and 1-phenyl-1-methylthio-2-butanone (6). 4-Phenyl-2-butanone (7), 1,3-diphenyl-2-propanone (9), and 1,3-diphenyl-1,3-propanedione (10) gave the corresponding triketones monohydrate (8) and (11). 1-Indanone (12), 2-indanone (13), and 1,3-indandione (14) gave ninhydrin (15) in good yields.In the case of 3-phenyl-1-indanone (16), 3-phenyl-2-bromo-1-indanone (17), 3-phenyl-2-bromo-1-indenone (18) and 3-phenyl-1-indenone (19) were obtained. 1-Phenyl-1-propanone (20) and 1-phenyl-1-butanone (22) gave the corresponding α-(methylthio)ketones (21) and (22). 1,3,3-Triphenylpropanone (24a) and 1-phenyl-3-methyl-1-butanone (24b) yielded only the corresponding α-bromoketones (25a,b) in good yields.These α-bromoketones, however, afforded the corresponding α-diketones (26a,b) in moderate yields when α-bromoketones reacted with dimethyl sulphoxide in the presence of AgBF4.