1422953-20-5

Basic information

• Product Name: 4-bromo-N,N-diethyl-3-methoxy-5-(methoxymethoxy)benzamide
• Synonyms: 4-bromo-N,N-diethyl-3-methoxy-5-(methoxymethoxy)benzamide
• CAS NO: 1422953-20-5
• Molecular Weight: 346.221
• Mol File: 1422953-20-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromo-N,N-diethyl-3-methoxy-5-(methoxymethoxy)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-N,N-diethyl-3-methoxy-5-(methoxymethoxy)benzamide(1422953-20-5)
• EPA Substance Registry System: 4-bromo-N,N-diethyl-3-methoxy-5-(methoxymethoxy)benzamide(1422953-20-5)

Safety Data

• Hazardous Substances Data: 1422953-20-5(Hazardous Substances Data)

Upstream product

• 1422953-19-2 4-bromo-3-methoxy-5-(methoxymethoxy)benzoic acid 
• 660-68-4 diethyl amine hydrochloride 
• 1422953-18-1 methyl 4-bromo-3-methoxy-5-(methoxymethoxy)benzoate 

Downstream Products

• 1422953-22-7 N,N-diethyl-3-hydroxy-5-methoxy-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzamide 
• 1422953-21-6 N,N-diethyl-3-methoxy-5-(methoxymethoxy)-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzamide 

Relevant articles and documents

Synthetic studies towards NG-121: Diastereoselective synthesis of NG-121 methyl ether

Starting from unsymmetrically O-protected methyl 4-bromo-3,5- dihydroxybenzoate, a facile synthesis of the methyl ether of bioactive natural product NG-121 was accomplished in very good overall yield. The key steps were: Stille coupling reaction of the farnesyl unit with the electron-rich phenolic segment; hydroxy-directed selective epoxidation of the farnesyl chain along with concomitant phenol-driven intramolecular regio- and diastereoselective ring closure to the corresponding hydroxybenzopyran; and regioselective formylation followed by in situ reductive lactonization. Georg Thieme Verlag KG · Stuttgart · New York.