1422962-02-4Relevant academic research and scientific papers
Facile synthesis of diverse isoindolinone derivatives via Ugi-4CR followed by Cu-catalyzed deamidative C(sp2)-C(sp3) coupling
Tyagi, Vikas,Khan, Shahnawaz,Chauhan, Prem M.S.
supporting information, p. 1279 - 1284 (2013/03/13)
The present work highlights a synthetic approach to the diverse isoindolinone derivatives using Ugi-4CR followed by a Cu-catalyzed deamidative C-C coupling reaction. This two-step sequence tolerates a broad range of amines, aldehydes, and isocyanides as starting materials for Ugi-4CR products to provide medicinally relevant isoindolinone derivatives in moderate to good yields.
