1311147-13-3Relevant academic research and scientific papers
Facile synthesis of diverse isoindolinone derivatives via Ugi-4CR followed by Cu-catalyzed deamidative C(sp2)-C(sp3) coupling
Tyagi, Vikas,Khan, Shahnawaz,Chauhan, Prem M.S.
, p. 1279 - 1284 (2013/03/13)
The present work highlights a synthetic approach to the diverse isoindolinone derivatives using Ugi-4CR followed by a Cu-catalyzed deamidative C-C coupling reaction. This two-step sequence tolerates a broad range of amines, aldehydes, and isocyanides as starting materials for Ugi-4CR products to provide medicinally relevant isoindolinone derivatives in moderate to good yields.
Nickel(0)-catalyzed cyclization of N -benzoylaminals for isoindolinone synthesis
Shacklady-Mcatee, Danielle M.,Dasgupta, Srimoyee,Watson, Mary P.
, p. 3490 - 3493 (2011/09/12)
A nickel(0) catalyst effectively mediates the cyclization of N-benzoyl aminals in the presence of a stoichiometric Lewis acid. This method enables preparation of a variety of isoindolinones with substitution on the benzoyl fragment and C-3 carbon. This reaction likely proceeds via an α-amidoalkylnickel(II) intermediate, which then may cyclize via either an electrophilic aromatic substitution or an insertion pathway.
