1422984-77-7Relevant academic research and scientific papers
Catalytic asymmetric synthesis of enantioenriched b-nitronitrile bearing a C-CF3 stereogenic center
Jakhar, Ajay,Kumari, Prathibha,Nazish, Mohd,Khan, Noor-ul H.,Kureshy, Rukhsana I.,Abdi, Sayed H. R.,Suresh
, p. 29977 - 29982 (2016)
CF3 substituted b-nitronitriles with an all-carbon quaternary stereogenic center have been synthesized via asymmetric cyanation reaction. In situ generated chiral TiIV salen complexes were used as catalysts for asymmetric addition of
Access to Chiral GABA Analogues Bearing a Trifluoromethylated All-Carbon Quaternary Stereogenic Center through Water-Promoted Organocatalytic Michael Reactions
Sim, Jae Hun,Park, Jin Hyun,Maity, Pintu,Song, Choong Eui
supporting information, p. 6715 - 6719 (2019/10/02)
Water enables the highly challenging enantioselective Michael addition of sterically congested β-trifluoromethyl-β-aryl- or -alkyl-substituted nitroolefins with dithiomalonates. Under on-water conditions, the reaction rates were remarkably accelerated as
The squaramide-catalyzed asymmetric Michael/cyclization tandem reaction for the synthesis of chiral trifluoromethylated hydroxyimino tetrahydrobenzofuranones
Liu, Wei,Lai, Xiaoyan,Zha, Gaofeng,Xu, Yan,Sun, Panpan,Xia, Tao,Shen, Yongcun
supporting information, p. 3603 - 3607 (2016/04/19)
An enantioselective synthesis of trifluoromethylated hydroxyimino tetrahydrobenzofuranones has been developed. 1,3-Dicarbonyl carbocyclic compounds react with β-CF3-β-disubstituted nitroalkenes in the presence of a chiral squaramide catalyst, p
Enantioselective Michael Addition of Pyrazolin-5-ones to β-CF3-β-Disubstituted Nitroalkenes Catalyzed by Squaramide Organocatalyst
Lai, Xiaoyan,Zha, Gaofeng,Liu, Wei,Xu, Yan,Sun, Panpan,Xia, Tao,Shen, Yongcun
supporting information, p. 1983 - 1988 (2016/08/09)
A highly enantioselective Michael addition of pyrazolin-5-ones with β-CF3-β-disubstituted nitroalkenes catalyzed by bifunctional squaramide has been developed. Various chiral β-CF3-β-5-hydroxy-pyrazolin-3-yl-disubstituted nitroalkane derivatives bearing all-carbon quaternary stereocenter were prepared in good yields (up to 88%) and excellent enantioselectivities (up to 97% ee).
Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines
Martinelli, Emilie,Vicini, Anna Chiara,Mancinelli, Michele,Mazzanti, Andrea,Zani, Paolo,Bernardi, Luca,Fochi, Mariafrancesca
, p. 658 - 660 (2015/01/09)
In the presence of a thiourea catalyst, β-CF3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of β-CF3 amine precursors with a tertiary stereocentre at the β-position. This reaction
Enantioselective organocatalytic reduction of β-trifluoromethyl nitroalkenes: An efficient strategy for the synthesis of chiral β-trifluoromethyl amines
Massolo, Elisabetta,Benaglia, Maurizio,Orlandi, Manuel,Rossi, Sergio,Celentano, Giuseppe
supporting information, p. 3589 - 3595 (2015/03/04)
An efficient organocatalytic stereoselective reduction of β-trifluoromethyl-substituted nitroalkenes, mediated by 3,5-dicarboxylic ester-dihydropyridines (Hantzsch ester type), has been successfully developed. A multifunctional thiourea-based (S)-valine d
Highly enantioselective construction of trifluoromethylated all-carbon quaternary stereocenters via nickel-catalyzed friedel-crafts alkylation reaction
Gao, Jian-Rong,Wu, Hao,Xiang, Bin,Yu, Wu-Bin,Han, Liang,Jia, Yi-Xia
supporting information, p. 2983 - 2986 (2013/04/10)
A highly enantioselective Friedel-Crafts alkylation reaction of indoles with β-CF3-β-disubstituted nitroalkenes was achieved using a Ni(ClO4)2-bisoxazoline complex as a catalyst, which afforded indole-bearing chiral compou
