128816-77-3

Basic information

• Product Name: 2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL) ETHANOL
• Synonyms: 2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL) ETHANOL
• CAS NO: 128816-77-3
• Molecular Formula: C₉H₉F₃O₂
• Molecular Weight: 206.16
• Mol File: 128816-77-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL) ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL) ETHANOL(128816-77-3)
• EPA Substance Registry System: 2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL) ETHANOL(128816-77-3)

Safety Data

• Hazardous Substances Data: 128816-77-3(Hazardous Substances Data)

Usage

General Description

2,2,2-Trifluoro-1-(3-methoxyphenyl) ethanol is a chemical compound with the molecular formula C9H9F3O2. It is a colorless liquid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL) ETHANOL is known for its ability to modify the properties of various materials due to its unique chemical structure. It is also utilized in the production of electronic materials and as a solvent in various industrial processes. However, due to its toxic and potentially hazardous nature, it should be handled with caution and in accordance with safety guidelines.

Upstream product

• 75-46-7 trifluoromethan 
• 591-31-1 3-methoxy-benzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 30724-22-2 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone 

Downstream Products

• 128816-78-4 Phosphoric acid bis-(2,2,2-trifluoro-ethyl) ester 2,2,2-trifluoro-1-(3-methoxy-phenyl)-ethyl ester 
• 1422985-22-5 3-(1,1,1-trifluoro-2-(3-methoxyphenyl)-3-nitropropan-2-yl)-1H-indole 
• 1422984-82-4 C₁₀H₁₀F₃NO₄ 
• 30724-22-2 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone 

Relevant articles and documents

Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction

A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared. The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction, affording the products bearing a trifluoromethylated all-carbon quaternary stereocenter with moderate to excellent yields (up to 99%) and good to excellent enantioselectivies (up to > 99.9% ee). Moreover, a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and Difluorocarbene Sources

The trifluoromethylation of carbonyl compounds is accomplished by the stable (trifluoromethyl)zinc reagent generated and then isolated from CF3I and ZnEt2, which can be utilized as a trifluoromethyl anion source (CF3-). The reaction proceeds smoothly with diamine as a ligand and ammonium salt as an initiator, providing the corresponding trifluoromethylated alcohol products. Moreover, the (trifluoromethyl)zinc reagent can also be employed as a difluorocarbene source (:CF2) not only for gem-difluoroolefination of carbonyl compounds with phosphine but also for gem-difluorocyclization of alkenes or alkynes via the thermal decomposition, respectively.