1422984-91-5Relevant academic research and scientific papers
The squaramide-catalyzed asymmetric Michael/cyclization tandem reaction for the synthesis of chiral trifluoromethylated hydroxyimino tetrahydrobenzofuranones
Liu, Wei,Lai, Xiaoyan,Zha, Gaofeng,Xu, Yan,Sun, Panpan,Xia, Tao,Shen, Yongcun
, p. 3603 - 3607 (2016)
An enantioselective synthesis of trifluoromethylated hydroxyimino tetrahydrobenzofuranones has been developed. 1,3-Dicarbonyl carbocyclic compounds react with β-CF3-β-disubstituted nitroalkenes in the presence of a chiral squaramide catalyst, p
Access to Chiral GABA Analogues Bearing a Trifluoromethylated All-Carbon Quaternary Stereogenic Center through Water-Promoted Organocatalytic Michael Reactions
Sim, Jae Hun,Park, Jin Hyun,Maity, Pintu,Song, Choong Eui
supporting information, p. 6715 - 6719 (2019/10/02)
Water enables the highly challenging enantioselective Michael addition of sterically congested β-trifluoromethyl-β-aryl- or -alkyl-substituted nitroolefins with dithiomalonates. Under on-water conditions, the reaction rates were remarkably accelerated as
Enantioselective Michael Addition of Pyrazolin-5-ones to β-CF3-β-Disubstituted Nitroalkenes Catalyzed by Squaramide Organocatalyst
Lai, Xiaoyan,Zha, Gaofeng,Liu, Wei,Xu, Yan,Sun, Panpan,Xia, Tao,Shen, Yongcun
supporting information, p. 1983 - 1988 (2016/08/09)
A highly enantioselective Michael addition of pyrazolin-5-ones with β-CF3-β-disubstituted nitroalkenes catalyzed by bifunctional squaramide has been developed. Various chiral β-CF3-β-5-hydroxy-pyrazolin-3-yl-disubstituted nitroalkane derivatives bearing all-carbon quaternary stereocenter were prepared in good yields (up to 88%) and excellent enantioselectivities (up to 97% ee).
Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines
Martinelli, Emilie,Vicini, Anna Chiara,Mancinelli, Michele,Mazzanti, Andrea,Zani, Paolo,Bernardi, Luca,Fochi, Mariafrancesca
, p. 658 - 660 (2015/01/09)
In the presence of a thiourea catalyst, β-CF3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of β-CF3 amine precursors with a tertiary stereocentre at the β-position. This reaction
Highly enantioselective construction of trifluoromethylated all-carbon quaternary stereocenters via nickel-catalyzed friedel-crafts alkylation reaction
Gao, Jian-Rong,Wu, Hao,Xiang, Bin,Yu, Wu-Bin,Han, Liang,Jia, Yi-Xia
supporting information, p. 2983 - 2986 (2013/04/10)
A highly enantioselective Friedel-Crafts alkylation reaction of indoles with β-CF3-β-disubstituted nitroalkenes was achieved using a Ni(ClO4)2-bisoxazoline complex as a catalyst, which afforded indole-bearing chiral compou
