150698-81-0

Usage

Uses

Used in Pharmaceutical Industry:
2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol is utilized as a solvent or intermediate in the production of pharmaceuticals. Its chemical structure allows it to be a key component in the synthesis of various medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol serves as an essential intermediate for the synthesis of agrochemicals. Its role in the production of these compounds helps in the development of effective pesticides, herbicides, and other agricultural products.
Used in Organic Chemistry:
2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol is employed as a reagent in organic chemistry. Its unique properties make it a valuable tool in the synthesis of a wide range of chemical compounds, facilitating research and development in the field.
Used in Medicine and Biotechnology:
Due to its potential pharmacological activity, 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol may have applications in the field of medicine and biotechnology. Its unique chemical properties could be harnessed for the development of new therapeutic agents and biotechnological processes.
However, it is crucial to handle 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol with caution, as it may pose health and environmental risks if not used and disposed of properly.

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 123-11-5 4-methoxy-benzaldehyde 
• 403648-66-8 (±)-trimethyl-2,2,2-trifluoro-1-(4-methoxyphenyl)ethoxysilane 
• 75-46-7 trifluoromethan 
• 455-13-0 4-Iodobenzotrifluoride 
• 844-40-6 diphenylmethanol trifluoroacetate 
• 74853-66-0 4'-trifluoromethyl-2,2,2-trifluoroacetophenone 

Downstream Products

• 74853-66-0 4'-trifluoromethyl-2,2,2-trifluoroacetophenone 
• 1422984-91-5 C₁₀H₇F₆NO₃ 
• 191402-60-5 1-(1-Chloro-2,2,2-trifluoro-ethyl)-4-trifluoromethyl-benzene 
• 1404446-80-5 5-bromo-2-methyl-3-nitro-6-[2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethoxy]pyridine 
• 158098-74-9 C₉H₆F₆O₂ 
• 666836-33-5 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethyl trifluoromethanesulfonate 

Relevant academic research and scientific papers

Five-membered heteroaromatic derivative, preparation method and application thereof

The invention belongs to the technical field of medicines, and particularly relates to a five-membered heteroaromatic compound, a composition, a preparation method and application thereof. The compound or the composition can be used as an inhibitor of a retinoid-related orphan receptor [gamma]t (ROR [gamma]t). The invention also relates to a method for preparing the compound and the composition, and application of the compound and the composition in treatment or prevention of ROR [gamma]t-mediated cancers, inflammations or autoimmune diseases of mammals, especially human beings.

Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands

The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.

One-Pot and Reducible-Functional-Group-Tolerant Synthesis of α-Aryl- and α-Heteroaryl-α-Trifluoromethyl Alcohols via Tandem Trifluoroacetylation and MPV Type Reduction

We have developed a new one-pot synthesis of α-aryl- and α-heteroaryl-α-trifluoromethyl alcohols carrying not only arenes with electron-withdrawing groups but also electron-deficient nitrogen-containing heteroarenes, which are of increasing interest becau

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling of Secondary α-(Trifluoromethyl)benzyl Tosylates

A palladium-catalyzed C(sp3)?C(sp2) Suzuki–Miyaura cross-coupling of aryl boronic acids and α-(trifluoromethyl)benzyl tosylates is reported. A readily available, air-stable palladium catalyst was employed to access a wide range of functionalized 1,1-diaryl-2,2,2-trifluoroethanes. Enantioenriched α-(trifluoromethyl)benzyl tosylates were found to undergo cross-coupling to give the corresponding enantioenriched cross-coupled products with an overall inversion in configuration. The crucial role of the CF3 group in promoting this transformation is demonstrated by comparison with non-fluorinated derivatives.

Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and Difluorocarbene Sources

The trifluoromethylation of carbonyl compounds is accomplished by the stable (trifluoromethyl)zinc reagent generated and then isolated from CF3I and ZnEt2, which can be utilized as a trifluoromethyl anion source (CF3-). The reaction proceeds smoothly with diamine as a ligand and ammonium salt as an initiator, providing the corresponding trifluoromethylated alcohol products. Moreover, the (trifluoromethyl)zinc reagent can also be employed as a difluorocarbene source (:CF2) not only for gem-difluoroolefination of carbonyl compounds with phosphine but also for gem-difluorocyclization of alkenes or alkynes via the thermal decomposition, respectively.

Photoinduced additive-free trifluoromethylation of aromatic aldehydes with TMSCF3

We report herein a new and effective method for additive-free trifluoromethylation of aromatic aldehydes with TMSCF3. Normal acidic hydrolysis for desilylation in the workup process is not required in this transformation. This reaction presents

Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines

In the presence of a thiourea catalyst, β-CF3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of β-CF3 amine precursors with a tertiary stereocentre at the β-position. This reaction

FUNGICIDAL COMPOSITIONS

The present invention provides a composition comprising a combination of components A) and B), wherein component A) is a compound of formula (I) and the component (B) is a further fungicide, insecticide or herbicide.

Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers

A new strategy towards [18F]trifluoromethyl-containing compounds is developed. [18F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [18/sup