1423131-78-5Relevant articles and documents
[3+2] Cycloadditions of α-acyl ketene dithioacetals with propargylamines: Pyrrole synthesis in water
Ren, Chuan-Qing,Di, Chong-Hui,Zhao, Yu-Long,Zhang, Jing-Ping
supporting information, p. 1478 - 1481 (2013/04/23)
A series of 2,3,4-trisubstituted and 1,2,3,4-tetrasubstituted pyrroles were synthesized via [3+2] cycloaddition of α-acyl ketene dithioacetals (or related substrates) with commercially available propargylamines as 1,3-dipoles in water. Most of the reactions can be performed in the absence of an external base. The reaction of secondary amine (N-methylprop-2-yn-1-amine) with α-acyl ketene dithioacetals showed different reaction behaviours depending on the addition or absence of an external base. Copyright