142314-70-3

Usage

Uses

Used in Chemical Synthesis:
Benzoic acid, 2-formyl-6-nitro-, methyl ester is used as a chemical intermediate for the synthesis of 6-bromomethylsalicylic acid and related substances. Its unique structure allows for further functionalization and modification, making it a valuable building block in the development of new organic compounds and materials.
In the Pharmaceutical Industry:
Benzoic acid, 2-formyl-6-nitro-, methyl ester can be used as a starting material for the synthesis of various pharmaceutical compounds. Its reactivity and functional groups enable the creation of new drug candidates with potential therapeutic applications.
In the Dye and Pigment Industry:
The compound may also find applications in the synthesis of dyes and pigments, where its chemical structure can be utilized to create novel colorants with specific properties.
In the Agrochemical Industry:
Benzoic acid, 2-formyl-6-nitro-, methyl ester can be employed in the development of agrochemicals, such as pesticides and herbicides, where its chemical properties can be exploited to target specific pests or weeds.

Upstream product

• 22351-62-8 3-nitro-phthalic acid-1-chloride-2-methyl ester 
• 61940-21-4 methyl 2-(bromomethyl)-6-nitrobenzoate 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 61940-22-5 methyl 2-methyl-6-nitrobenzoate 
• 6744-85-0 2-(methoxycarbonyl)-3-nitrobenzoic acid 

Downstream Products

• 846055-77-4 2-(4-tert-butyl-phenyl)-8-nitro-2H-phthalazin-1-one 
• 846055-82-1 methyl 2-(2-methoxyvinyl)-6-nitrobenzoate 
• 1056123-60-4 methyl 2-nitro-6-(2-oxoethyl)benzoate 
• 1233858-24-6 8-nitro-2-(3-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1233858-26-8 8-amino-2-(3-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1233858-14-4 N-(1-oxo-2-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinolin-8-yl)pyrazine-2-carboxamide 
• 1233858-30-4 8-amino-2-(3-(trifluoromethyl)phenyl)phthalazin-1(2H)-one 
• 1233858-16-6 N-(4-oxo-3-(3-(trifluoromethyl)phenyl)-3,4-dihydrophthalazin-5-yl)pyrazine-2-carboxamide 
• 1233858-28-0 8-nitro-2-(3-(trifluoromethyl)phenyl)phthalazin-1(2H)-one 

Relevant academic research and scientific papers

NOVEL PIPERIDINE-2,6-DIONE DERIVATIVE AND USE THEREOF

The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.

PHTHALAZINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for e

Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide

(Chemical Equation Presented) The development of efficient methods for the facile construction of important molecular frameworks is an important goal in organic synthesis. Chiral 3-substituted phthalides are widely distributed in a large collection of natural products with broad, potent, and potentially path-pointing biological activities. In this investigation, we have uncovered an unprecedented organocatalytic asymmetric aldol-lactonization reaction of 2-formylbenzoic esters with ketones/aldehydes for convenient construction of the enantioenriched "privileged" scaffold. As a result of the sensitive nature of substrate structures of an organocatalytic enantioselective aldol reaction, after extensive optimization of reaction conditions, catalyst L-prolinamide alcohol IV is identified as the best promoter. Interestingly, it is found that in this reaction, addition of an acid additive PhCO2H can significantly enhance reaction efficiency with use of only as low as 2.5 mol % IV for the process. Moreover, due to the sensitivity of reaction conditions toward a sequential aldol-lactonization process without affecting enantioselectivity and racemization, it is essential to remove the catalyst for the subsequent facile lactonization reaction in the presence of K 2CO3. The aldol-lactonization processes serve as a powerful approach to the preparation of synthetically and biologically important 3-substitued phthalides with a high level of enantioselectivities. A 3-step catalytic asymmetric synthesis of the natural product of 3-butylphthalide is reported.

PHTHALAZINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for e

Substituted quinolinone derivatives and methods of use

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and