1423160-48-8

Basic information

• Product Name: 2-(4-(3-((5-(4-(tert-butoxy)phenyl)-1,3,4-oxadiazol-2-yl)thio)propyl)piperazin-1-yl)benzo[d]oxazole
• CAS NO: 1423160-48-8
• Molecular Weight: 493.63
• Mol File: 1423160-48-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-(3-((5-(4-(tert-butoxy)phenyl)-1,3,4-oxadiazol-2-yl)thio)propyl)piperazin-1-yl)benzo[d]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(3-((5-(4-(tert-butoxy)phenyl)-1,3,4-oxadiazol-2-yl)thio)propyl)piperazin-1-yl)benzo[d]oxazole(1423160-48-8)
• EPA Substance Registry System: 2-(4-(3-((5-(4-(tert-butoxy)phenyl)-1,3,4-oxadiazol-2-yl)thio)propyl)piperazin-1-yl)benzo[d]oxazole(1423160-48-8)

Safety Data

• Hazardous Substances Data: 1423160-48-8(Hazardous Substances Data)

Upstream product

• 13205-47-5 4-tert-butoxybenzoic acid 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 62370-08-5 methyl 4-tert-butoxybenzoate 
• 111628-39-8 2-(1-piperazinyl)-1,3-benzoxazole 
• 1423160-41-1 C₁₂H₁₄N₂O₂S 
• 1423160-39-7 2-(4-(3-bromopropyl)piperazin-1-yl)benzo[d]oxazole 

Relevant articles and documents

Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: Novel hybrid heterocycles as anticancer agents

The synthesis of a series of substituted 2-(piperazin-1-yl)benzothiazole/ benzoxazole coupled with 1,3,4-oxadiazole-2-thiol pharmacophore (8a-t) is described using a three carbon spacer (Jones and Helm, Drugs 69:1903-1910, 2009). The structures of the compounds were confirmed by NMR and mass spectral data. All the synthesized compounds have been evaluated for their cytotoxicity towards five human cancer cell lines of different origins, viz. MCF-7 (Breast), HeLa (Cervical), HepG2 (Liver), A431 (Skin) and A549 (Lung), and IC50 values were determined. Among the compounds tested, 8j and 8t displayed maximum cytotoxic activity. A431 was the most sensitive cell line against the compounds studied, followed by MCF7, A549, HepG2 and HeLa.