142326-59-8 Usage
Uses
L-701,324 is a potential anticonvulsant with high selectivity and affinity for the NMDA receptor glycine site. NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment.
Biological Activity
An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 142326-59-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,3,2 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 142326-59:
(8*1)+(7*4)+(6*2)+(5*3)+(4*2)+(3*6)+(2*5)+(1*9)=108
108 % 10 = 8
So 142326-59-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
142326-59-8Relevant articles and documents
Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions
Lange, Jos H.M.,Verveer, Peter C.,Osnabrug, Stefan J.M.,Visser, Geb M.
, p. 1367 - 1369 (2007/10/03)
3-Aryl-4-hydroxyquinolin-2(1H)-ones are potent and selective glycine-site NMDA receptor antagonists of pharmaceutical interest. A novel microwave-enhanced synthesis of such quinolinones under solvent-free conditions has been developed. The quinolinones ar
Hydroxyquinolone derivatives compounds which have pharmaceutical utility
-
, (2008/06/13)
This present invention relates to a class of 4-hydroxy-2-(1H)-quinolones which are substituted in the 3-position by an optionally substituted aryl substituent. These compounds are selective non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors.
