1423287-20-0Relevant articles and documents
The effect of absolute configuration on activity, subtype selectivity (M3/M2) of 3α-acyloxy-6β-acetoxyltropane derivatives as muscarinic M3 receptor antagonists
Wang, Zhi-Peng,Liu, Hui-Zhong,Zhu, Liang,Hu, You-Min,Cui, Yong-Yao,Niu, Yin-Yao,Lu, Yang,Chen, Hong-Zhuan
, p. 1234 - 1239 (2013/03/14)
Both enantiomers of 3α-acyloxy-6β-acetoxyltropane derivatives 1-4 were prepared respectively and underwent functional studies and radioreceptor binding assays. 6S Enantiomers showed obvious muscarinic M3, M2 antagonistic activity, while the 6R ones elicit