142335-42-0

Basic information

• Product Name: BOC-7-HYDROXY-TIC-OH
• Synonyms: BOC-[3S]-1,2,3,4-TETRAHYDROISOQUINOLINE-7-HYDROXY-3-CARBOXYLIC ACID;BOC-7-HYDROXY-(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;BOC-7-HYDROXY-TIC-OH;BOC-L-7-HYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;BOC-HYDROXY-TIC-OH;BOC-L-TIC(7-OH)-OH;BOC-L-TIC(OH)-OH;BOC-TIC(7-HYDROXY)-OH
• CAS NO: 142335-42-0
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol File: 142335-42-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 496.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.302±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 2.91±0.20(Predicted)
• CAS DataBase Reference: BOC-7-HYDROXY-TIC-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-7-HYDROXY-TIC-OH(142335-42-0)
• EPA Substance Registry System: BOC-7-HYDROXY-TIC-OH(142335-42-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 142335-42-0(Hazardous Substances Data)

Usage

General Description

BOC-7-HYDROXY-TIC-OH is a chemical compound with the systematic name tert-butyloxycarbonyl-7-hydroxy-3-(2,3,4,9-tetrahydro-1H-carbazol-4-yl)propanoic acid. It is commonly used in the field of peptide chemistry as a protecting group for amino acids, particularly in the synthesis of peptides and proteins. The BOC-7-HYDROXY-TIC-OH compound is important for introducing specific functionalities into peptide chains, allowing for selective chemical reactions and control over the desired properties of the final peptide product. Its use in peptide synthesis has been widely documented in scientific literature and it is a valuable tool for researchers and practitioners in the field of biochemistry and pharmaceutical development.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 34619-03-9 tert-butyldicarbonate 
• 128502-56-7 (3S)-1,2,3,4-tetrahydro-7-hydroxy-isoquinoline-3-carboxylic acid 
• 142335-40-8 (S)-1,2,3,4-Tetrahydro-7-hydroxy-6,8-diiodoisoquinoline-3-carboxylic acid 
• 300-39-0 3,5-diiodo-l-tyrosine 
• 262616-16-0 methyl (S)-2-tert-butoxycarbonyl-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 142335-41-9 (S)-2-(tert-butoxycarbonyl)-7-hydroxy-6,8-diiodo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 

Downstream Products

• 1287261-12-4 (S)-2-benzyl-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 1287261-51-1 (S)-tert-butyl 2-((2S,3S)-1-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-1-oxopentan-2-ylcarbamoyl)pyrrolidine-1-carboxylate 
• 1287261-52-2 methyl 2-((S)-2-((2S,3S)-2-((S)-2-(tert-butoxycarbonylamino)-3-methylbutanamido)-3-methylpentanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate 
• 1287261-53-3 tert-butyl 4-((2S,3S)-1-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-1-oxopentan-2-ylcarbamoyl)piperidine-1-carboxylate 
• 1287261-22-6 (S)-tert-butyl 2-((2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-1-oxopentan-2-ylcarbamoyl)pyrrolidine-1-carboxylate 
• 1287261-23-7 tert-butyl (S)-1-((2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate 
• 1287261-24-8 tert-butyl 4-((2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-1-oxopentan-2-ylcarbamoyl)piperidine-1-carboxylate 
• 1287261-25-9 (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-2-((2S,3S)-3-methyl-2-((S)-pyrrolidine-2-carboxamido)-pentanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride 
• 1287261-26-0 (S)-2-((2S,3S)-2-((S)-2-amino-3-methylbutanamido)-3-methylpentanoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride 
• 1287261-27-1 (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-2-((2S,3S)-3-methyl-2-(piperidine-4-carboxamido)pentanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride 
• 1287261-59-9 methyl 2-((S)-2-((2S,3S)-2-(tert-butoxycarbonylamino)-3-methylpentyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate 
• 1287261-61-3 methyl 2-((S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate 
• 1287261-28-2 tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate 
• 1287261-29-3 (S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 

Relevant articles and documents

Photophysics of 7-hydroxytetrahydroisoquinoline-3-carboxylic acid and its derivatives

The following derivatives of 7-hydroxytetrahydroisoquinoline-3-carboxylic acid {Tic(OH) [I]}, a conformationally restricted analogue of tyrosine, were synthesized for the purpose of photophysical studies and in order to elucidate the nature of tyrosine fluorescence and its decay: Ac-Tic(OH) [II], Ac-Tic(OH)-NHMe [III], Tic(OH)-NHMe [IV], Ala-Tic(OH) [V], Ac-Ala-Tic(OH) [VI], and Tic(OH)-Gly-NH2 [VII]. For the simple Tic(OH) derivatives I-IV, the N-methylamide was found to be a more effective quencher than the acetyl group. For the peptidic derivatives V-VII the highest quenching of the fluorescence of the phenolic chromophore was observed in the case of Ala-Tic(OH). The simple Tic(OH) derivatives I-IV were also the subject of theoretical studies (MOPAC 93). The obtained thermodynamic parameters (MOPAC calculations) and the fluorescence components were discussed on the basis of the rotamer theory in order to explain the participation of an individual rotamer in the complex process of the fluorescence decay of tyrosine.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

PROTEOLYSIS-TARGETING CHIMERAS

The present disclosure provides compounds of the formula (I) wherein these compounds contain a ligand which binds to one or more target proteins such as CDK4 or CDK6 and a ligand which binds to the machinery associated with the ubiquitinating protein machinery. Also provided herein are methods of using these compounds in compositions or methods of treating patients with these compounds for the treatment of a disease or disorders such as cancer.