14235-05-3

Basic information

• Product Name: Carbonochloridic acid, 3-nitrophenyl ester
• CAS NO: 14235-05-3
• Molecular Formula: C7H4ClNO4
• Molecular Weight: 201.566
• Mol File: 14235-05-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Carbonochloridic acid, 3-nitrophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonochloridic acid, 3-nitrophenyl ester(14235-05-3)
• EPA Substance Registry System: Carbonochloridic acid, 3-nitrophenyl ester(14235-05-3)

Safety Data

• Hazardous Substances Data: 14235-05-3(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 554-84-7 meta-nitrophenol 
• 75-44-5 phosgene 

Downstream Products

• 309965-22-8 3-Nitrophenyl N-(2-hydroxybenzyl)-N-methylcarbamate 
• 4694-91-1 6-nitro-3H-benzooxazol-2-one 
• 28955-71-7 4-nitrobenzo[d]oxazol-2(3H)-one 
• 1158077-03-2 3-nitrophenyl 4-methylpiperazine-1-carboxylate 
• 64459-24-1 tetrahydro-1-(5-t-butyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-(3-nitrophenoxycarbonyloxy)-2(1H)-pyrimidinone 

Relevant articles and documents

Cu(II)-promoted methanolysis of N, N -bis(2-picolyl)carbamates: Rate-limiting metal ion delivery of coordinated alcoholate nucleophile followed by fast partitioning of a tetrahedral intermediate

Five O-aryl/alkyl N,N-bis(2-picolyl)carbamates were prepared with the O-aryl/alkyl portions being p-nitrophenoxy, m-nitrophenoxy, trifluoroethoxy, methoxy, and isopropoxy (4a,b,c,d,e, respectively) and the kinetics and reaction products of their methanolysis reactions in the presence of Cu(O3SCF3)2 determined. The catalyzed reactions have maximal rates for each substrate at a 1:1 ratio of [4]:[Cu2+] at sspH 7.9, where the active forms are Cu(II):4:(-OCH3). The reactions are fast, that for the complex of 4a having a t1/2 of 30 s. The products of the reaction with 4a and 4b arise exclusively from C-OAr cleavage: those with 4d and 4e arise exclusively from C-N cleavage. With 4c, products from both C-O and C-N cleavage are observed in a 2.17:1 ratio. The common mechanism involves rate-limiting delivery of a Cu(II)-coordinated methoxide to the C=O unit to form a tetrahedral intermediate followed by fast partitioning to products by two pathways with relative barriers dependent on the sspKaHOAr/HOR. The data allow one to predict an effective sspKa of ～15.6 for the sspKaNH of Cu(II):bis(2-picolyl)amine.

DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS

Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

Topical compositions comprising protected functional thiols

This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr)m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.