1423720-72-2

Upstream product

• 1423720-71-1 (S)-tert-butyl 4-(3,5-diiodo-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 1426447-08-6 (S)-tert-butyl 4-(3,5-dibromo-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate 

Downstream Products

• 1423720-74-4 (S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate 
• 1423720-68-6 (S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid 
• 1423720-69-7 (S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-oxopropan-2-yl)carbamate 
• 1426447-10-0 (S)-tert-butyl (1-hydroxy-3-(3,4,5-trimethoxyphenyl)propan-2-yl)carbamate 
• 477254-82-3 (S)-2-((tert-butoxycarbonyl)amino)-3-(3,4,5-trimethoxyphenyl)propanoic acid 
• 1423720-73-3 (S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate 

Relevant academic research and scientific papers

An efficient synthesis of l-3,4,5-trioxygenated phenylalanine compounds from l-tyrosine

A new strategy for the synthesis of l-3,4,5-trioxygenated phenylalanine derivatives from l-tyrosine is developed for the first time. The approach, featuring the transformation of aryl diiodide to bis-phenol via a one-pot procedure including lithiation, boronation, and oxidation, is highly practical. By this robust protocol, N-protected l-3,5-bis(tert-butyldimethylsilyloxy)-4- methoxy-phenylalanine and l-3,4,5-trimethoxy-phenylalanine derivatives were obtained from l-tyrosine in 9 steps with 36-40% overall yields.