142386-80-9

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 142386-79-6 1-D,L-α-tocopherylglycerol 
• 142386-77-4 2,3-isopropylidene-1-D,L-α-tocopherolglycerol 

Downstream Products

• 142386-78-5 [1-(4,4'-dimethoxytrityl)]-2-succinyl-3-D,L-α-tocopherylglycerol 
• 850544-45-5 [1-(4,4'-dimethoxytrityl)]-(3-D,L-α-tocopheryl)glycerol-2-phosphoramidite 

Relevant academic research and scientific papers

Attachment of vitamin E derivatives to oligonucleotides during solid-phase synthesis

Compounds have been synthesized which allow the attachment of Vitamin E to the 5'-, and 3'-ends of oligonucleotides, and the attachment of a Vitamin E moiety on an octamethylene spacer to the 5'-end, all during solid-phase synthesis. The effects on cellul

NUCLEIC ACID OF FORMULA (I): GlXmGn, OR (II): ClXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT

The present invention relates to a nucleic acid of the general formula (I): GlXmGn, or (II): ClXmCn, which may be modified by a lipid. The nucleic acid of the invention acts as an immune-stimulating agent inducing the innate immune response. The invention relates further to a pharmaceutical composition (in a first embodiment), each containing an immune-stimulating agent according to the invention in combination with a pharmaceutically active carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). In another embodiment, the inventive nucleic acid is combined with at least one pharmaceutically active component, a pharmaceutically acceptable carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). Accordingly, the present invention is directed to a vaccine, which corresponds to a pharmaceutical composition of the invention (second embodiment), wherein the pharmaceutically active component induces a specific immune response (e.g. an antigen). The present invention relates likewise to the use of a nucleic acid of the invention or a pharmaceutical composition according to the invention for the treatment of infectious diseases, autoimmune diseases, allergies or cancer diseases.

ADJUVANT IN THE FORM OF A LIPID-MODIFIED NUCLEIC ACID

The present invention relates to an immune-stimulating adjuvant in the form of a lipid-modified nucleic acid, optionally in combination with further adjuvants. The invention relates further to a pharmaceutical composition and to a vaccine, each containing an immune-stimulating adjuvant according to the invention, at least one active ingredient and optionally a pharmaceutically acceptable carrier and/or further auxiliary substances and additives and/or further adjuvants. The present invention relates likewise to the use of the pharmaceutical composition according to the invention and of the vaccine according to the invention for the treatment of infectious diseases or cancer diseases. Likewise, the present invention includes the use of the immune-stimulating adjuvant according to the invention in the preparation of a pharmaceutical composition for the treatment of cancer diseases or infectious diseases.