1424024-68-9Relevant academic research and scientific papers
Ruthenium Catalyzed Selective α- And α,β-Deuteration of Alcohols Using D2O
Chatterjee, Basujit,Gunanathan, Chidambaram
, p. 4794 - 4797 (2015)
Highly selective ruthenium catalyzed α-deuteration of primary alcohols and α,β-deuteration of secondary alcohols are achieved using deuterium oxide (D2O) as a source of deuterium and reaction solvent. Minimal loading of catalyst (Ru-macho), base (KOtBu), and low temperature heating provided efficient selective deuteration of alcohols making the process practically attractive and environmentally benign. Mechanistic studies indicate the D-O(D/R) bond activations by metal-ligand cooperation and intermediacy of carbonyl compounds resulting from dehydrogenation of alcohols.
Simple and efficient catalytic reaction for the selective deuteration of alcohols
Khaskin, Eugene,Milstein, David
, p. 448 - 452 (2013/08/25)
A highly efficient system for the catalytic deuteration of α and β CH bonds of primary and secondary alcohols has been developed. The deuterium source is D2O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d6. The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.
