142408-92-2

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[3-[4-[4-methoxy-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]phen oxy]propyl]-, 1,1-dimethylethyl ester, (S)-
• CAS NO: 142408-92-2
• Molecular Formula: C32H44N2O7
• Molecular Weight: 568.711
• Mol File: 142408-92-2.mol

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[3-[4-[4-methoxy-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]phen oxy]propyl]-, 1,1-dimethylethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[3-[4-[4-methoxy-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]phen oxy]propyl]-, 1,1-dimethylethyl ester, (S)-(142408-92-2)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[3-[4-[4-methoxy-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]phen oxy]propyl]-, 1,1-dimethylethyl ester, (S)-(142408-92-2)

Safety Data

• Hazardous Substances Data: 142408-92-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 142374-17-2 4-{3-[4-((S)-2-Benzyloxycarbonylamino-4-diazo-3-oxo-butyl)-phenoxy]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 7037-49-2 3-(piperidin-4-yl)propan-1-ol 
• 2629-72-3 4-(3-Hydroxypropyl)pyridine 
• 156185-63-6 N-Boc-piperidin-4-yl-propanol 
• 142374-14-9 4-(3-iodo-propyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 142374-15-0 methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester 
• 142374-16-1 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid 

Downstream Products

• 1025988-45-7 4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1026303-40-1 4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-methoxycarbonyl-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 142408-93-3 4-{3-[4-((S)-2-Benzyloxycarbonylamino-3-carboxy-propyl)-phenoxy]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 1027603-46-8 4-{3-[4-((S)-2-Amino-3-methoxycarbonyl-propyl)-phenoxy]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp

Inhibitors of platelet-fibrinogen binding offer an opportunity to interrupt the final, common pathway for platelet aggregation.Small molecule inhibitors of the platelet fibrinogen receptor GPIIb/IIIa were prepared and evaluated for their ability to prevent platelet aggregation.Compound 23m (L-700, 462/MK-383) inhibited in vitro platelet aggregation with an IC50 of 9 nM and demonstrated a selectivity of >24000-fold between platelet and human umbilical vein endothelial cell fibrinogen receptors.Dose-dependent inhibition of ex vivo platelet aggregation induced by ADP was achieved with iv infusions 0.1-10 μg/kg/min of 23m in anesthetized dogs, with 10 μg/kg/min completely inhibiting platelet aggregation during the entire 6 h infusion protocol.Platelet aggregatability returned rapidly after the termination of the 23m infusions.These features suggest that 23m may be useful in the treatment of arterial occlusive disorders.